Jiangnan University

Max Planck Institute of Colloids and Interfaces

Peter Seeberger

Jian Yin

Jing Hu

Heung Sik Hahm

Claney Lebev Pereira

Chakkumkal Anish

Sharavathi Guddehalli Parameswarappa

Chunjun Qin

Benjamin Schumann

Xiaopeng Zou

Zhou Ye

Kevin Pagel

Subramanian Govindan

Johanna Hofmann

The present disclosure discloses the chemical synthesis method of theserotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of, and the like.

Chemical synthesis method ofserotype O51 O-antigen oligosaccharide

The disclosure discloses a preparation method of outer core octasaccharide oflipopolysaccharide, and belongs to the field of carbohydrate chemistry. The structure of the outer core octasaccharide ofis (&#x3b1;-D-Glc-(1-3)-&#x3b1;-D-Glc-(1-4)-&#x3b2;-D-Gal-(1-7)-D-&#x3b1;-D-Hep[&#x3b1;-D-Glc-(1-6)-&#x3b1;-D-Glc-(1-6)-&#x3b1;-D-Glc-(1-2)-D-&#x3b1;-D-Hep]-Linker. The structure consists of three monosaccharides: glucose, galactose and heptose. It contains five &#x3b1;-glycosidic bonds of glucose, one &#x3b2;-glycosidic bond of galactose and two &#x3b1;-glycosidic bonds of heptose. The disclosure prepares the octasaccharide by the synergistic action of remote neighboring group participation effect, solvent effect, temperature effect, additives and leaving groups. The reducing end of the octasaccharide may also be linked with a linker for future attachment to the protein to form a glycoconjugate for immunological studies.

Preparation method of outer core octasaccharide of Helicobacter pylori lipopolysaccharide

The present disclosure discloses an integrated nano system for liver-targeting co-delivery of genes/drugs and a preparation method, belonging to the field of biomedicines. In the disclosure, a plurality of functions are integrated in a carrier having good biocompatibility and safety, a nucleic acid/drug-loading copolymer portion having a pH-stimulating response function is formed by poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) grafted with poly(3-azido-2-hydroxypropylmethacrylate) (PGMA-N3), and a fluorescence-based imaging component Rhodamine B (RhB) and galactose are used as targeting ligands. The drug delivery system provided by the present disclosure is safe, is capable of taking a synergistic effect of gene/drug therapy, and is expected to play a great role in clinical application.

Integrated nano system for liver-targeting co-delivery of genes/drugs and preparation method

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Potsdam, Germany

Peter Seeberger