The General Hospital Corporation

Dsm IP Assets B.v.

Microbia, Inc.

Peter Scott Yorgey

John Jeffrey Talley

Mark G Currie

Frederick M Ausubel

Timothy Claude Barden

Brian Cali

Daniel P Zimmer

Bastien Chevreux

Wayne Schairer

Jessica Leigh McGrath

Eduardo Martinez

Stephen Antonelli

Regina Lundrigan-Soucy

Jing-Jing Yang

Alejandro Aballay

Jessica Leigh Mc Grath

The present invention relates to the use of novel promoters for heterologous gene expression, preferably for expression of genes in organisms of the genus, to the genetically modified organisms of the genus, and to a process for producing biosynthetic products by cultivating the genetically modified organisms.

Promoters suitable for heterologous gene expression in yeast

4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.

4-Biarylyl-1-phenylazetidin-2-ones

Disclosed are screening methods for identifying the interplay between environmental and host signals (e.g., host-dependent or host-independent signals) and physiological pathogenic pathways that control or regulate genes responsible for establishing a persistent infection, as in the colonization of the gut of the nematode.

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Growing community of inventors

Cambridge, MA, United States of America

Peter Scott Yorgey