Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Sanofi-a Ventis Deutschland Gmbh

Peter Schindler

Hartmut Strobel

Ursula Schindler

Gerhard Huber

Alexander Muelsch

Andreas W Herling

Horst Hemmerle

Wolfgang Konig

Laszlo Vertesy

Francoise Delevallee

Hans-Wolfram Fehlhaber

Jurgen Blumbach

Herbert Kogler

Roland Utz

Robert Rippel

Karl Sch&ouml;nafinger

The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.

Method for screening for activators of soluble guanylate cyclase having oxidized heme iron

Luminescent method of detecting soluble guanylate cyclase

Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments

Method for detecting oxidized forms of soluble guanylate cyclase

Cyclohexane derivatives of the formula I ##STR1## in which the radicals R.sup.1 to R.sup.6, X, Y and Z have the stated meanings, and processes for the preparation of these compounds are described. The compounds have valuable pharmacological properties and can therefore be used as pharmaceuticals.

Substituted cyclohexane derivatives, processes for their preparation and

Substituted cyclohexane derivatives for the treatment of diseases Esters of cyclohexane derivatives of the formula I ##STR1## in which A--B, R.sup.3, R.sup.4, R.sup.5, Y and Z have the meanings indicated, for use as inhibitors of the glucose-6-phosphatase system of the liver in mammals are described. The compounds are suitable for the production of pharmaceutical preparations.

Substituted cyclohexane derivatives for the treatment of diseases

The invention relates to new biologically active glycopeptides of the general formula

Enkastins: new glycopeptides which act to inhibit enkephlinase,

What are disclosed are cephalosporin derivatives of the formula ##STR1## formulations containing such cephem derivatives suitable for the detection of .beta.-lactamases, process for the manufacture of the cephem derivatives and the formulations, and use of the cephem derivatives for the detection of .beta.-lactamases and .beta.-lactamase inhibitors.

Chromogenic cephalosporin compound

A method for isolating a chemically unstable carbapenem antibiotic from a fermentation solution by adsorbing the antibiotic on an ion exchanger resin at the maximum of product formation, thus converting it to a stabilized form, and then separating the resin from the fermentation solution.

Isolation of chemically unstable antibiotics from fermentation solutions

The invention relates to chromophoric peptides of the general formula I ##STR1## in which n represents 1 or 2, a porcess for their preparation, agents containing them and their use for determining DD-carboxypeptidases.

Chromophoric peptides, a process for their preparation, agents

A chromophoric cephalosporin composition having the formula ##STR1## is utilized for the detection of .beta.-lactamases. Detection of .beta.-lactomases can be carried out by diluting the compound in solution or by a test strip carrier.

Detection of .beta.-lactamase utilizing a chromophoric cephalosporin

What are disclosed are cephalosporins of the formula ##STR1## processes for the manufacture of said cephalosporins, preparations containing same for the detection of .beta.-lactamases, a process for making said preparations, and the use of said cephalosporins for the detection of .beta.-lactamases.

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Bad Soden, Germany

Peter Schindler