Beckman Coulter, Inc.

Dh Technologies Development Pte. Ltd.

Peter S Kotowski

Sunil S Deliwala

Chitra Kumari Ratnayake

Brian D Peterson

Craig A Hudson

Anna X Lou

Jane Luo

Dale Alan Owens

Jean-Marc Rene Lucien Busnel

James H Reyes

Stephen A Frye

Clive Cheung

Tom Tran

Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Some embodiments use a high voltage isolated CE power supply that is configured to float on the high voltage output of an ESI-MS power supply, with a protective resistance in the ESI-MS path, as well as DC/DC converter isolation and communication system isolation for the isolated CE power supply. Some embodiments additionally use a cartridge assembly integrating separation and conductive fluid capillaries with fluid cooling and protective retractable housings for the capillary end portions and for the ESI output. The protective housing may further be used with an adapter for interfacing with different MS systems.

Capillary electrophoresis-electrospray ionization-mass spectrometry system

Aspects of the present innovations relate to improved systems that may perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Embodiments may use a current sense circuit at a high voltage output from an MS-ESI power supply in conjunction with additional elements to identify fault conditions associated with leakage current, to confirm the continuity of CE connections, and to provide improved system protection.

Leakage current sense circuit for error detection in an improved capillary electrophoresis-electrospray ionization-mass spectrometry system

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Yorba Linda, CA, United States of America

Peter S Kotowski