Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Peter S Kormoczy

Gabor Kovacs

Istvan Stadler

Sandor Virag

Istvan Szekely

Karoly Horvath

Pal Hadhazy

Krisztina Kekesi

Istvan Hermecz

Dezso Korbonits

Laszlo Tardos

Katalin Marmarosi Nee Kellner

Sandor Botar

Gyula Papp

Vera Gergely

Laszlo Szekeres

Vilmos Simonidesz

Jozsef Gaal

Istvan Tomoskozi

Jeno Marton

Geza Galambos

Peter Gyory

Lorand Debreczeni

Zoltan Vargai

Csaba Szantay

Pal Kiss

Zoltan Kapui

Gergely Heja

Kalman Takacs

Gabor Horvath

Katalin Marmarosi

Imre Bata

Sandor Antus

Lajos Novak

Agnes Gottsegen

Zoltan Torok

Jozsef Lengyel

Marianna Lovasz Nee Gaspar

Jozsef Ivanics

Karoly Kanai

Laszlo Fesus

Emil Minker

Istvan Sziraki

Gyorgy Dorman

Kalman Magyar

Csaba Vertesi

Janos Ori

Maria Szabo

Judit Skopal

Anna Z Szabo

Istvan Szatmari

Zsolt Bencze

Maria H Pap

Judit Szeredy Nee Varga

Iloma Kiss neAjzert

Mariann Lovasz Nee Gaspar

Istvan Rakoczi

Laszlo Muszbek

Gaza Galambos

Jozsef Aszodi

Eva Udvari

Istvan Rakoczy

Eva Udvary

Andrea Bolehovszky

Pharmaceutical composition and process for the preparation thereof

The invention relates to novel compounds of the general formula (I), ##STR1## wherein R means hydrogen or a straight or branched chain C.sub.1-6 alkoxy group;

Isoquinoline compounds, compositions and use

The invention relates to novel diphenylpropylamine derivatives of the general formula (I). ##STR1## R.sup.1 stands for hydrogen or a methyl group; R.sup.2 stands for hydrogen, a methyl or n-decyl group;

Diphenkylpropylamines for the therapy of heart disease

The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I ##STR1## and pharmaceutically acceptable salts thereof wherein A stands for C.sub.1-4 alkylene and

Oxadiazole-alkyl-purine derivatives useful as antitussive agents

The invention relates to new 7-oxo-PGI.sub.2 -ephedrine salt analogues of the Formula I ##STR1## wherein A stands for --(CH.sub.2).sub.2 --, cis or trans --CH.dbd.CH-- or --C.tbd.C--;

7-oxo-PGI.sub.2 -ephedrine salts and their pharmaceutical compositions

The invention relates to new, 7-substituted PGI.sub.2 -derivatives of formula (I) ##STR1## The new compounds have valuable therapeutical properties, and in particular show prostacyclin-like effects.

7-Substituted PGI.sub.2 -derivatives and pharmaceutical compositions

2,3,4-trinor-1,5-inter-m-phenylene-prostacycline derivatives of the formula (I), ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1-4 alkyl group, an alkali metal cation or a primary, secondary, tertiary or quaternary ammonium cation,

2,3,4-Trinor-m-inter-phenylene-prostaglandin derivatives and

The invention relates to a process for the preparation of novel 4-oxo-PGI.sub.2 derivatives of formula I ##STR1## where (a) compounds of formula III ##STR2## are oxidized, then the obtained 5-substituted-4-oxo-PGI.sub.1 derivatives of general formula II ##STR3## are eliminated by the splitting off of the W-H-molecule, or (b) the compounds of formula IV ##STR4## are reacted in a solvent in the presence of a catalyst with compounds of general formula V ##STR5## then the obtained compounds of formula I are transformed if desired by saponification, hydrolysis, salt formation, insertion of a protection group to another compound which belongs to the compounds of formula I, too. The pharmaceutical products of the invention can be used for the treatment of circulatory diseases, they inhibit the aggregation of blood plaques, dilate the bronchi and inhibit the secretion of gastric acid.

4-Oxo-PGI.sub.2 compounds, their use in inhibition of thrombii and their

The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms;

13-Thia-prostacycline derivatives

A compound having vasodilative, bronchodilative, stomach-mucosa-protective and platelet-aggregation-inhibiting activity has the formula A 4-thia- or 4-sulfinyl-PGI.sub.1 -compound of the formula I ##STR1## wherein Q stands for --S-- or --SO--,

Vasodilative 4-thia-PGI.sub.1 and 4-sulfinyl-PGI.sub.1 and derivatives

Growing community of inventors

Budapest, Hungary

Peter S Kormoczy