Scarista Limited

Paloma Pharmaceuticals, Inc.

Nanodesign Inc.

Peter Redden

Austin McMordie

Mehar Manku

Andrea Pitt

Paul Wakefield

Paul Bradley

Philip Knowles

Miklos Feher

Fupeng Ma

Robert Dunn-Dufault

David I Sherris

Jonathan Martin Schmidt

Julie Mercure

Shuguang Zhu

John Whelan

Natalie Lazarowych

Manjinder Gill

Jonathan Schmidt

Sanjivanjit Kaur Bhal

Sherri Clarkson, Legal Representative

David B Horrobin

Sherri Clarkson

Described herein are compositions and methods for preventing and/or treating diseases involving aberrant angiogenesis employing one or more benzo[c]chromen-6-one derivatives.

Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis

The invention relates to compounds of formula: wherein Ris selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein Ris selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.

1,3-propane diol esters and ethers and methods for their use in drug delivery

The invention relates to compounds of formula:wherein Ris selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein Ris selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.

1,3-Propane diol esters and ethers and methods for their use in drug delivery

Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines and endothelial cells and methods of synthesis are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of cancer through either anti-angiogenesis or other anti-cancer mechanisms. The compounds specified are 6H-dibenzo&lsqb;b,d&rsqb;pyran-6-one derivatives and have been shown to be antiproliferative against human endothelial cells.

Dibenzo&lsqb;c&rsqb;chromen-6-one derivatives as anti-cancer agents

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Oakville, Canada

Peter Redden