Chiron Corporation

University of North Carolina at Chapel Hill

Cetus Oncology Corporation

Genentech, Inc.

Cetus Corporation

Cetus Onocology Corporation

Chiron Corporation/chapel Hill North Carolina

Peter Ralph

John Stephen Haskill

George A Martin

Kong T Chong

Danute E Nitecki

Albert S Baldwin

James W Larrick

Alice M Wang

Martha B Ladner

Robert Zimmerman

Janelle N Van Arsdell

Michael Piatak

James Devlin

Mary K Warren

James J Devlin

David B Ring

Ernest S Kawasaki

Mazie Yee Coyne

Mary Kim Warren

Ada H Kung

Sharon Auckerman

Sylvia Hsieh Ma

Sharon Lea Aukerman

Joanna Mizen Watson

Ernest S Kaswasaki

Mazie Y Coyne

The instant invention describes an analytical assay to accurately measure an analyte in the presence of an interfering substance.

Analytical method

Medicaments and methods of using the same are disclosed for treating or preventing diseases resulting from undesirable cell adhesion of IL-1 receptor positive cells to biological materials, particular to endothelial cells, or autoimmune related diseases, preferably graft versus host disease, or IL-1 dependent cancers.

Method for down regulating CD4 expression in a T cell

Multifunctional proteins having M-CSF activity and at least one other bioactivity not found together in a single naturally occuring molecule are described. These multifunctional M-CSF proteins can be produced by the expression of fused genes which are also described. These multifunctional M-CSF proteins have increased therapeutic potential.

Multifunctional M-CSF proteins and genes encoding therefor

Two novel cytokines which are involved in an inflammatory response (inflammatory cytokines) are disclosed. The inflammatory cytokines have been isolated from activated peripheral blood, preferably monocytes adhered to plastic; or peripheral blood leukocytes induced with calcium ionophore and mezerin. The two cytokines are Gro .beta. and .gamma., and their cDNA and amino acid sequences are disclosed. The expression of the genes in various cells is presented. Assay and diagnostic utilities using the cytokines; recombinant materials and procedures; purification procedures; and monoclonal antibodies to the cytokines are also shown.

Gro genes

Compositions involving I.kappa.B (i.e., inhibitor of Nuclear Factor-.kappa.B or NF-.kappa.B) and methods of using the same are described that have applications for the identification of prophylactics or therapeutics for the treatment of diseases resulting from altered gene expression, including genes that encode cytokines or related molecules.

Inhibitor of NF-.kappa.B transcriptional activator and uses thereof

Gro genes, proteins, and uses thereof

Method of purifying Gro .beta. or Gro .alpha. protein using antibodies

Method for attenuating a cellular response to IL-1

The present invention is directed to DNA, host cells and a vector encoding a protein with cytokine inhibitory activity, particularly IL-1 inhibitory activity. The protein encoded by the DNA of the present invention is particularly useful as an IL-1 antagonist.

DNA, host cell and vector encoding a protein with cytokine inhibitory

IL-1 receptor antagonists medicaments

Compositions and methods of using the same are described that have applications for the identification of prophylactics or therapeutics for the treatment of diseases resulting from altered gene expression, including genes that encode cytokines or related molecules.

Method of identifying a chemical that alters dissociation of an

A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, viral or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.

Uses of recombinant colony stimulating factor-1

Growing community of inventors

Orinda, CA, United States of America

Peter Ralph