3m Innovative Properties Company

Kindeva Drug Delivery, L.p.

Peter R Johnson

Ying Di Zhang

Moses Mekala David

Mark J Pellerite

Larry D Boardman

Percy T Fenn

Franklyn L Frederickson

Zheng Zhi Wu

James T Wolter

Adam S Cantor

Ted K Ringsred

Ying Zhang

Daniel C Duan

Joan T Moseman

Mark Eugene Mueller

Gary A Korba

Nayna Govind

Ryan T Woldt

Hye-Ok Choi

Kristen J Hansen

Amy S Determan

John K Simons

Marla R Emery

Jennifer E Raeder-Devens

Kirsten J Hansen

Ravi Ravichandran

Zheng Z Wu

A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

Microneedle device having a peptide therapeutic agent and an amino acid and methods of making and using the same

Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 sand a temperature of 25&#xb0; C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50&#xb0; or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.

Aqueous formulations for coating microneedle arrays

Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same

Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same

Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.

Coatable compositions, coatings derived therefrom and microarrays having such coatings

An applicator used to apply microneedle arrays to a mammal. In particular, an application device for applying a microneedle device to a skin surface comprising a flexible sheet having a raised central area attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

Low-profile microneedle array applicator

An applicator () used to apply microneedle arrays () to a mammal. In particular, an application device for applying a microneedle device () to a skin surface comprising a flexible sheet () having a raised central area () attached to the microneedle device and a supporting member at or near the periphery of the flexible sheet, wherein the flexible sheet is configured such that it will undergo a stepwise motion in the direction orthogonal to the major plane of the sheet.

A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.

Masking method for coating a microneedle array

A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.

Process for making chemically stable C-17/21 OH 20-ketosteroid aerosol products

C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability

Growing community of inventors

Eagan, MN, United States of America

Peter R Johnson