Recurium IP Holdings, LLC

Immunome, Inc.

Pfizer Corporation

Recurium IP Holding, LLC

Zeno Management, Inc.

Peter Qinhua Huang

Kevin Duane Bunker

Joseph Robert Pinchman

Chad Daniel Hopkins

Rakesh Kumar Sit

Deborah Helen Slee

Sunny Abraham

Sayee Gajanan Hegde

Ahmed Abdi Samatar

Suvi Tuula Marjukka Orr

Kimberlee Fischer

Xiaojun Han

Mehmet Kahraman

Brant Clayton Boren

Aditya Krishnan Unni

Robert Steven Kania

Sunil Paliwal

Guobao Zhang

Robert Louis Hoffman

Michael Raymond Collins

Aaron Craig Burns

Pei-Pei Kung

Maria Angelica Linton

Daniel Lee Severance

Hui Liu

Daniel Tyler Richter

Paul Francis Richardson

Samantha Elizabeth Greasley

Graham Smith

Lakshmi Sourirajan Narasimhan

Benjamin Pratt

Chuangxing Guo

Fernando Donate

Mark Charles Grier

Jiali Li

Sobhana Babu Boga

Jianhui Ma

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as cancer and tumors, as well as viral infections such as HIV.

Benzamide compounds

Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tertiary alcohols can be used to prepare synthetic versions of natural products and/or pharmaceuticals.

Chiral synthesis of a tertiary alcohol

Immunoconjugates of the Formula (I) include a linking group for linking an antibody targeting ligand (Ab) to a drug (D). Embodiments of such immunoconjugates are useful for delivering the drug to selected cells or tissues, e.g., for the treatment of cancer.Ab-[S-L-L-L-L-L-L-L-D]   (I)

Immunoconjugates and methods

Disclosed herein are nitrogen-containing bicyclic compounds of Formula (I), including pharmaceutically acceptable salts thereof, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

EGFR inhibitor compounds

Compounds of Formula (I) are estrogen receptor alpha modulators, where the variables in Formula (I) are described in the disclosure. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions that are estrogen receptor alpha dependent and/or estrogen receptor alpha mediated, including conditions characterized by excessive cellular proliferation, such as cancer.

Estrogen receptor modulators

Immunoconjugates of the Formula (I) include a linking group for linking an antibody targeting ligand (Ab) to a drug (D). Embodiments of such immunoconjugates are useful for delivering the drug to selected cells or tissues, e.g., for the treatment of cancer.Ab-[S-L-L-L-L-L-L-L-D]&#x2003;&#x2003;(I)

Processes of making [1.1.1]propellane utilize reaction conditions that include reacting 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane with an effective amount of solid magnesium.

Process for making [1.1.1]propellane

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as cancer and tumors, as well as viral infections such as HIV. 

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San Diego, CA, United States of America

Peter Qinhua Huang