Corixa Corporation

Oncoresponse, Inc.

Leland Stanford Junior University

Glaxosmithkline Biologicals Sa

Peter Probst

Ajay Bhatia

Yasir A W Skeiky

Steven G Reed

Davin C Dillon

Antonio Campos-Neto

John R Webb

Mark E Branum

Tyrel T Smith

Randi M Simmons

Melissa L Conerly

Siddarth Chandrasekaran

Kamal D Puri

Yasir A Skeiky

Rhea N Coler

Steven P Fling

Erika Jean Stromberg

Craig A Smith

Mark R Alderson

Steven R Wiley

Martine Marchand

Yves Lobet

Pascal Mettens

Shyian Jen

Jean-Francois Lucien Maisonneuve

Ajamete Kaykas

Florence Bernadette Nozay

Mark Brannon

Brenda Maisonneuve

Yasir A W Sheiky

Rhea M Coler

Erica Jean Stromberg

Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.

Immunomodulatory antibodies and methods of use thereof

Human CD163 antibodies and uses thereof

Provided herein are antibodies and methods of use thereof. The antibodies as disclosed herein bind to CD163+ on cells, such as on macrophages. These antibodies can be used in methods of treatment, such as methods of treating cancer.

The present invention relates to compositions comprising proteins or polynucleotides ofsp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis ofinfection.

Vaccines against chlamydial infection

Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.

CD47 related compositions and methods for treating immunological diseases and disorders

Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of aantigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

Compounds and methods for treatment and diagnosis of chlamydial infection

Compounds and methods for treatment and diagnosis of Chlamydial infection

Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

Leishmania antigens for use in the therapy and diagnosis of leishmaniasis

Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

Compounds for the diagnosis of Chlamydial infection

Growing community of inventors

Seattle, WA, United States of America

Peter Probst