Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Dsm IP Assets B.v.

Rempex Pharmaceuticals, Inc.

Patheon Austria Gmbh & Co. Kg

Dpx Holdings B.v.

Peter Poechlauer

Wolfgang Skranc

Irma Wirth

Herbert Mayrhofer

Rudolf Neuhofer

Sascha Braune

Stefan Steinhofer

Mehul Thathagar

Quirinus B Broxterman

Herfried Griengl

Wolfgang Kroutil

Philipp Selig

Ulfried Felfer

Kerstin Steiner

Martina Kotthaus

Thomas Heinrich Pabst

Andreas Pelz

Rafael Wilhelmus E G Reintjens

Nicole Theodora W Linssen

Marcus Hanacek

Florian Seebauer

Rafael Wilhelmus Elisabeth Ghislain Reintjens

Walther Jary

George Winkler

Thorsten Ganglberger

Bas Ritzen

Michel Goldbach

Martin Fechter

Christopher Zinganell

Clemens Stueckler

Julia Pitzer

Anton Glieder

Quirinus Bernardus Broxterman

Georg Winkler

Nicole Theodora Wilhelmina Linssen

The present invention relates to a process for biocatalytic amidation of non-protected amino acids comprising the step of contacting a non-protected amino acid with an ammonia source in the presence of an organic solvent and an enzyme.

Single step biocatalytic amidation

A process for a continuous production of a boronic acid derivative based on a Matteson boronic ester homologation and an apparatus of performing the process are disclosed.

Apparatus and continuous flow process for production of boronic acid derivatives

A process for the continuous production of a compound of Formula (II), HO&#x2014;R&#x2014;ONO(II) wherein Ris a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO&#x2014;R&#x2014;OH (I) wherein Ris as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.

Formation of nitrate esters in microreactors and millireactors using a continuous product extraction in a turbulent flow regime

A process for the preparation of a cyclopropane derivative of Formula (I), by reacting an olefin of Formula (II), with a carbene of the formula:CRR, in a reaction vessel, optionally in the presence of a solvent, wherein, Rand Rare each independently hydrogen, C-Calkyl, C-Calkenyl, aryl, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, &#x2014;C(O)Ror &#x2014;NR; R, R, Rand Rare each independently hydrogen, C-Calkyl, C-Calkoxy, C-Calkenyl, aryl, aryloxy, heteroaryl, heterocyclyl, carbocyclyl, heterocyclyl, &#x2014;C(O)R, &#x2014;NR, &#x2014;SR, &#x2014;S(O)R, or &#x2014;SOR, or Rand Rare as defined above and Rand Rtogether form a ring, which ring is carbocyclyl, heterocyclyl, aromatic or heteroaromatic; Ris hydrogen, hydroxy, C-Calkyl, C-Calkoxy, aryl, aryloxy, heteroaryl or &#x2014;NR; Ris hydrogen, C-Calkyl, C-Calkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; Ris hydrogen, hydroxy, C-Calkyl, C-Calkoxy, aryl, aryloxy or heteroaryl; Ris hydrogen, C-Calkyl, C-Calkenyl, aryl, heteroaryl, carbocyclyl, heterocyclyl or C(O)R; Ris hydrogen, C-Calkyl, C-Calkenyl, aryl, heteroaryl, carbocyclyl or heterocyclyl; and Ris hydrogen, hydroxy, C-Calkyl, C-Calkoxy, aryl, or aryloxy, in the presence of copper metal or copper oxide, wherein the process is a continuous process. 

Process for the production of cyclopropane derivatives

A tube bundle falling film microreactor for performing gas-liquid reactions, which has: a) at least one vertical tube with b) a device for distributing the liquid on the inside of the tube and c) a liquid collecting system, and d) a device for gas supply and removal, and use thereof.

Tube bundle falling film microreactor for performing gas liquid reactions

Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.

Process for the production of compounds via hazardous intermediates in a series of microreactors

A process for catalytically oxidizing alkylaromatic compounds of the formula (I)Ar&#x2014;CH&#x2014;Rwhere Ar is an optionally substituted, aromatic or heteroaromatic 5-membered or 6-membered ring or a ring system having up to 20 carbon atoms where Ar may optionally be fused to a C-C-alkyl group in which up to 2 carbon atoms may be replaced by a heteroatom, and R is hydrogen, phenyl, benzyl or heteroaryl, where the phenyl, benzyl or heteroaryl radicals may also be joined to Ar by a bridge, or R together with Ar forms an optionally substituted ring system which may contain one or more optionally substituted heteroatoms, to the corresponding aromatic or heteroaromatic carboxylic acids in a solvent with ozone in the presence of a transition metal catalyst and optionally in the presence of an acid at a temperature between &#x2212;70&#xb0; C. and 110&#xb0; C. to the corresponding carboxylic acid.

Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis

A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I),  where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C&#x2013;C-alkyl, alkenyl or alkynyl radical, where one or more carbon atoms in the chain can be replaced by an oxygen atom, a nitrogen atom, a sulfur atom, an SO or an SOgroup, an unsubstituted or substituted aryl or heteroaryl radical or heterocyclic radical or halogen, hydroxyl, NR5R6, acetyl, oxo, C&#x2013;C-carbalkoxy, C&#x2013;C-carbalkoxyamino, COOR7, cyano, amide, benzoylamino or NO, R5 and R6 are H, C&#x2013;C-alkyl radical, phenyl radical, benzyl radical or COOR7, or together form a C&#x2013;C-alkylene or heteroalkylene radical, R7 is H or C&#x2013;C-alkyl, n is 0, 1, 2 or 3, X, Y and Z can be an unsubstituted or substituted carbon atom or a radical selected from the group consisting of N, O, S or NR5R6, where R5 and R6 are as defined above, SO or SO, and at least one of the radicals X, Y and Z is not a carbon atom, where the compounds of the formula (I) can have one or more double bonds in the ring, with the proviso that in a 5-membered ring the double bond is not conjugated with the &#x2014;C(OH)CN-group, and/or can be anellated and/or bridged, by reacting a ketone of the formula (II),  where R1, R2, R3, R4, X, Y, Z and n have the meanings above, with an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous or two-phase system, or in emulsion, in the presence of a cyanide group donor.

Process for preparing heterocyclic (R)- and (S)-cyanohydrins

A process for preparing protected, enantiomer-enriched cyanohydrins of the formulawhere R1 and R2 independently of one another can be an unsubstituted, monosubstituted or polysubstituted C-C-alkyl, C-C-aryl, C-C-heteroaryl, C-C-alkaryl, C-C-alkylheteroaryl or C-C-aralkyl radical or an unsubstituted, monosubstituted or polysubstituted C-C-heterocycle, or C-C-alkylheterocycle or together can be an unsubstituted or substituted C-C-alkylene radical, which can contain one or more heteroatoms in the chain, or one of the radicals is hydrogen, and R3 can be an unsubstituted or substituted C-C-alkyl, C-C-aryl or C-C-heteroaryl radical, by reacting an aldehyde or ketone of the formulawhere R1 and R2 are defined as above, in the presence of an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous or 2-phase system or in emulsion at a temperature of &#x2212;5 to +40&#xb0; C. with a carbonic ester nitrile of the formulawhere R3 is defined as above.

Process for preparing protected, enantiomer-enriched cyanohydrins by in-situ derivatization

Process for the preparation of chiral &agr;-hydroxycarboxylic acids

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Linz, Austria

Peter Poechlauer