Behringwerke Aktiengesellschaft

Dade Behring Marburg Gmbh

Behring Diagnostics Gmbh

Peter Pfleiderer

Klaus Bosslet

Gerhard Seemann

Peter Hermentin

Hans H Sedlacek

Bernhard Auerbach

Rolf Muller

The invention relates to monoclonal antibodies against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), to the preparation and use thereof and to the use of the epitope defined by the antibody for diagnosis and therapy.

Monoclonal antibodies against tumor-associated antigens, processes for

The invention relates to the epitope which binds monoclonal antibody BW 835, DSM ACC 2022, and the use of the epitope for diagnosis and therapy.

Epitope which binds to monoclonal antibody

The invention relates to polynucleotides encoding the BW 835 variable domain of an antibody against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), and expression vectors containing the polynucleotides.

Polynucleotides encoding the anti-PEM antibody BW835 variable domains

The invention relates to a method of using a pair of leucine zipper peptides for in vitro diagnosis, in particular, for the immunochemical detection and determination of an analyte in a biological liquid. In one method, the first leucine zipper peptide is immobilized by attaching it to a solid support, the second leucine zipper peptide is coupled to a specific binding partner for the analyte, the two peptides are brought into contact, the sample of the biological liquid is brought into contact with the immobilized first peptide and the specific binding partner for the analyte, and the amount of analyte bound to the binding partner is determined. The leucine zipper peptides are preferably v-fos and c-jun.

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Marburg, Germany

Peter Pfleiderer