Sancilio & Company, Inc.

Micelle Biopharma, Inc.

Peter Persicaner

Janice Louise Cacace

Frederick D Sancilio

Mohand Dahim

Compositions including at least one Omega-3 fatty acid ester and at least one surface active agent are provided; wherein the compositions form micelles when in contact with an aqueous medium. Also provided is a method of administering to a subject such a composition, wherein the at least one Omega-3 fatty acid ester forms micelles when in contact with an aqueous medium, and the bioavailability of the at least one Omega-3 fatty acid ester is substantially independent of a food effect. The compositions are useful for treating cardiovascular conditions or disorders in a subject and for reducing side effects associated with the ingestion of Omega-3 fatty acid esters. Further provided are also various dosage forms for administering the compositions and use of the compositions in functional foods. Provided herein are also kits with instructions on how to administer the compositions.

Omega-3 fatty acid ester compositions

Stable micelles of fatty acid esters for the treatment of disease states

Stable micelles of mixed fatty acids

Functional foods and kits containing stable micelles of fatty acid esters

Stable micelles of fatty acid esters

Stable micelles of fatty acid esters for the treatment of cardiovascular disease

Stable micelles of fatty acid esters for the treatment of macular degeneration and primary sclerosing cholangitis

Stable micelles of fatty acid esters for the treatment of non-alcoholic fatty liver diseases

Compositions comprising at least one Omega-3 fatty acid ester and at least one surface active agent; wherein the compositions form micelles when in contact with an aqueous medium are taught. Also provided is a method of administering to a subject a composition comprising at least one Omega-3 fatty acid ester and at least one surface active agent, wherein the at least one Omega-3 fatty acid ester forms micelles when in contact with an aqueous medium, and the bioavailability of the at least one Omega-3 fatty acid ester is substantially independent of a food effect. The compositions are useful for treating cardiovascular conditions or disorders in a subject and for reducing side effects associated with the ingestion of Omega-3 fatty acid esters. Also taught are various dosage forms for administering the compositions and use of the compositions in functional foods. Also contemplated are kits for administering the compositions.

Described herein are compositions comprising at least one Omega-3 fatty acid ester and at least one surface active agent; wherein the compositions form micelles when in contact with an aqueous medium. Also provided is a method of administering to a subject a composition comprising at least one Omega-3 fatty acid ester and at least one surface active agent, wherein the at least one Omega-3 fatty acid ester forms micelles when in contact with an aqueous medium, and the bioavailability of the at least one Omega-3 fatty acid ester is substantially independent of a food effect. The compositions are useful for treating cardiovascular conditions or disorders in a subject and for reducing side effects associated with the ingestion of Omega-3 fatty acid esters. Described are also various dosage forms for administering the compositions and use of the compositions in functional foods. Provided herein are also kits with instructions on how to administer the compositions.

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Boca Raton, FL, United States of America

Peter Persicaner