Aptevo Research and Development LLC

Peter Pavlik

Danielle Mitchell

John W Blankenship

David Bienvenue

Gabriela Hernandez-Hoyos

Catherine J McMahan

Elaine Todd Sewell

The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

CD123 binding proteins and related compositions and methods

Methods of treatment of CD123 overexpressing disorders

Growing community of inventors

Seattle, WA, United States of America

Peter Pavlik