Pierre Fabre Medicament

Peter Pauwels

Bernard Vacher

Serge Halazy

Bernard Bonnaud

Marc Marien

Michel Perez

Gareth W John

Michael Briley

Jean-Pierre Valentin

Catherine Jorand

The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

Imidazolic compounds and use thereof as alpha-2 adrenergic receptors

The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): 

The invention provides compounds having the formula (1): wherein R1 is hydrogen, fluoro or methoxyl, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or methyl; R3 is hydrogen, methyl or ethyl; and their pharmaceutically acceptable acid addition salts, hydrates of their pharmaceutically acceptable acid addition salts as well as the isomers and the tautomers thereof.

Imidazolic compounds and use thereof as alpha-2-adrenergic receptors

Aromatic ethers derived from indoles which are useful as medicaments

Piperazides derived from arylpiperazine, processes for their

Indole-derived arylpiperazines as ligands for 5HT.sub.1 -like,

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Chessenaz, France

Peter Pauwels