Purac Biochem Bv

Sulzer Chemtech Ag

Peter Paul Jansen

Jan Van Breugel

André Banier De Haan

Paulus Loduvicus Johannes Van Der Weide

Agustín Cerdà Baró

Andre Banier De Haan

Agustin Cerda Baro

José Maria Vidal Lancis

José María Vidal Lancis

Paulus Loduvicus Van Der Weide

Willem Jacob Groot

Jose Maria Vidal Lancis

Tanja Dekic Zivkovic

Agustin Cerdà Baró

Siebe Cornelis De Vos

Adriaan Dirk Kon

Robert Edgar Haan

Peter Willi Kreis

Bert Theo De Vegt

Eloy E Urbano Cruz

Gerard Hendrik Van Bochove

Sarah Lanfranchi

Augustín Cerdà Baró

Sarah Borer

Tanja ÐEkic Zivkovic

The invention pertains to a method for providing a succinic acid solution, comprising the steps of &#x2014;providing a first magnesium succinate containing medium with a magnesium succinate concentration of 18-23 wt. % to a first acidification reactor where it is contacted with hydrogen chloride to form a solution of succinic acid, magnesium chloride and hydrogen chloride, &#x2014;providing a second magnesium succinate containing medium with a magnesium succinate concentration of 25-50 wt. %, and contacting it in a second acidification reactor with the solution of succinic acid, magnesium chloride and hydrogen chloride withdrawn from the first acidification reactor, to form an aqueous mixture comprising magnesium chloride and succinic acid with a succinic acid concentration of at least 18 wt. %. The method according to the invention makes it possible to obtain a solution comprising succinic acid and magnesium 20 chloride with an increased succinic acid concentration.

Method for providing a succinic acid solution

The invention provides a method for preparing a carboxylic acid, which method includes the steps of providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate has a solubility in water at 20&#xb0; C. of 80 g/100 g water or less; acidifying the magnesium carboxylate with HCl, thereby obtaining a solution comprising carboxylic acid and magnesium chloride (MgCl); optionally a concentration step, wherein the solution comprising carboxylic acid and MgClis concentrated; precipitating the carboxylic acid from the solution comprising the carboxylic acid and MgCl, thereby obtaining a carboxylic acid precipitate and a MgClsolution.

Acid/salt separation

The invention pertains to a method for preparing succinic acid which comprises providing an aqueous magnesium succinate solution to an acidification step, wherein the magnesium succinate solution is acidified by the addition of hydrogen chloride, thereby obtaining an aqueous solution comprising succinic acid and magnesium chloride and subjecting the aqueous solution comprising succinic acid and magnesium chloride derived from the acidification step to a treatment step with active carbon followed by precipitating succinic acid from an aqueous mixture comprising succinic acid and magnesium chloride resulting from the active carbon treatment step in a precipitation step to form solid succinic acid. It has been found that the method according to the invention leads to succinic acid crystals with better properties than a comparable method wherein no active carbon treatment is used.

Method for manufacturing succinic acid

Continuous process of forming aliphatic polyesters The process includes continuously providing cyclic ester monomer and polymerization catalyst to a continuous mixing loop reactor (CMLR) having static mixing elements and operated at a temperature between 100 and 240&#xb0; C. to form a pre-polymerized reaction mixture. The conversion is between 40 and less than 90 wt. %, wherein the cyclic ester monomer comprises lactide having a free acid content lower than 50 milli-equivalents per kg. The pre-polymerized reaction mixture is continuously provided to a plug flow reactor that is a static mixer reactor having static mixing elements and is operated at a temperature between 110-240&#xb0; C., wherein the reaction mixture is polymerized to a conversion of at least 90%, to form polymer wherein the flow ratio of the CMLR and the plug flow reactor is between 1.5 an d50. The process includes continuously removing polymer from the plug flow reactor devolitizing the polymer.

Process for the continuous production of polyesters

The invention provides a method for preparing a succinic acid, which method includes the steps of: providing magnesium succinate; acidifying the magnesium succinate with hydrochloric acid (HCl), thereby obtaining a solution including succinic acid and magnesium chloride (MgCl); optionally a concentration step, wherein the solution including succinic acid and MgClis concentrated; precipitating succinic acid from the solution including succinic acid and MgCl, thereby obtaining a succinic acid precipitate and a MgClsolution. The addition of HCl to a magnesium salt of succinic acid and subsequent precipitation of succinic acid from the solution leads to a very efficient separation of succinic acid from a magnesium succinate solution.

A fermentation process includes contacting a carbohydrate source with a microorganism in an aqueous fermentation broth to form a fermentation product which is a salt or a product with a boiling point above the boiling point of water. The fermentation process is carried out at a pressure which is below atmospheric pressure and at least at the value where the reaction medium is at its boiling point at the fermentation temperature. Water is evaporated and removed from the reactor during the fermentation in an amount which is at least 20% of the volume of liquid present in the reactor at the start of the fermentation. A fermentation process at reduced pressure while removing a substantial amount of water removes a surplus of water in the system, ensures removal of reaction heat, and may lead to improved fermentation quality.

Fermentation process at reduced pressure

A method for preparing a carboxylic acid by acidification of a liquid feed including a carboxylate salt, which method includes the steps of providing a liquid feed including magnesium carboxylate; providing a gas feed including gaseous hydrogen chloride; and acidifying the carboxylate to carboxylic acid by bringing the liquid feed into contact with the gas feed, thereby forming a liquid effluent including carboxylic acid and magnesium chloride, wherein the gas feed including gaseous hydrogen chloride is derived from a thermal decomposition step wherein an aqueous liquid including magnesium chloride is subjected to a temperature of at least 300&#xb0; C., thereby decomposing magnesium chloride into magnesium oxide and hydrogen chloride, thus obtaining a solid including magnesium oxide and a gas comprising gaseous hydrogen chloride.

Carboxylate acidification

A method for preparing a carboxylic acid, includes the steps of: providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate is selected from the group made of 2,5-furandicarboxylic acid, fumaric acid, adipic acid, itaconic acid, citric acid, glutaric acid, maleic acid, malonic acid, oxalic acid and fatty acids having more than 10 carbon atoms; acidifying the magnesium carboxylate with hydrogen chloride (HCl), thereby obtaining a solution including carboxylic acid and magnesium chloride (MgCl); optionally a concentration step, wherein the solution including carboxylic acid and MgClis concentrated; and precipitating the carboxylic acid from the solution including the carboxylic acid and MgCl, thereby obtaining a carboxylic acid precipitate and a MgClsolution.

The invention relates to a method for the preparation of a stable alkali metal lactate in powder form, the product of said preparation, functional pre-mixes for foodstuff comprising said stable alkali metal lactate powder, and foodstuffs comprising said stable alkali metal lactate powder. In the method according to the invention, a concentrate that contains alkali metal lactate is processed, with cooling, in a mixer/extruder to form a powder of the alkali metal lactate. According to the invention the alkali metal lactates in powder form are stable for at least 48 hours.

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Oss, Netherlands

Peter Paul Jansen