Amo Development, LLC

Advanced Liquid Logic, Inc.

Peter-Patrick De Guzman

Hong Fu

Zsolt Bor

Michael A Campos

John Michael Tamkin

Anthony W Dennison

Mikhail Levin

Victor J Kardos

Bing Wang

Robert G Heitel

Michael F Brownell

Uichong B Yi

Hon M Lee

Wayne Po-Wen Liu

Victor Kardos

Anthony Dennison

Kimberley N Patterson

M Lee Hon

A system and method for performing ophthalmic surgery using an ultra-short pulsed laser is provided. The system includes a laser engine configured to provide an ultra-short pulsed laser beam, optics configured to direct the laser beam to an undocked eye of a patient, an eye tracker configured to measure five degrees of freedom of movement of the undocked eye, an optical coherence tomography module configured to measure depth of the undocked eye, and a controller configured to control laser beam position on the undocked eye toward a desired laser pattern based on depth and the five degrees of freedom of movement of the undocked eye. Adaptive optics are also provided. Also disclosed are a scleral ring including fiducial markings and a compliant contact lens and fluid tillable contact lens configured to facilitate ultra-short pulsed laser surgery while reducing or eliminating eye docking requirements.

System and method for ophthalmic laser surgery employing eye tracking without eye docking

Embodiments of this invention relate to systems and methods for automatic depth (or Z) detection before, during, or after laser-assisted ophthalmic surgery. When performing ophthalmic laser surgery, the operator (or surgeon) needs to make accurate and precise incisions using the laser beam. With the automatic depth detection systems and methods, the same laser used for the surgical procedure may be used for depth measurement of the surgical incisions. The surgical laser system may include a laser delivery system for delivering a pulsed laser beam to photoalter an eye, a mirror to transmit at least a portion of reflected light of the pulsed laser beam, a lens positioned to focus the transmitted reflected lighted on to a detector, (such as a CCD), and a depth encoder configured to automatically detect depth according to one or more of color, intensity, or shape of the focused spot on the CCD.

System and methods for depth detection in laser-assisted ophthalmic procedures

Systems and methods for analyzing the anatomy of a patient's eye with circular or rotated polarized laser beams, or with laser beams of different wavelengths are disclosed. One system includes a polarization beam-splitter and a quarter-wave plate, wherein the quarter-wave plate is configured to circularly rotate a laser beam received from a laser that is transmitted and passes through the polarization beam-splitter, and to transform a circularly rotated back-reflected beam to a linearly polarized laser beam that is perpendicular to the beam that was transmitted through the polarization beam-splitter. Substantially all of the back-reflected beam is directed to a photo-detector for analysis. A Faraday rotator subsystem may be substituted for a polarization beam-splitter. An optical system including a laser that generates a laser beam of a first wavelength for therapeutic treatment, and another laser that generates a laser beam of a second wavelength for measurement is also disclosed.

Ophthalmic range finding

Molecular adsorption to the microfluidic device surfaces can be passively and actively mitigated by mixing certain hydrophilic polymers (organic polymers with repeating hydrophilic groups&#x2014;the preferred polymers being amphipathic surfactants&#x2014;with the sample liquid during or prior to relevant microfluidic operations. Nonionic surfactants such as polyoxyethylene sorbitan monooleate and polyoxyethylene octyl phenyl ether are especially effective. High molecular weight polyethylene polymers are also effective. The hydrophilic polymers appear to prevent binding of the fouling molecules to the microfluidic by occupying the surface sites in place of the fouling molecules or by interacting with the fouling molecules to prevent binding of the fouling molecules the surface. When surface adsorption is thus mitigated, microfluidic devices can readily handle samples containing biomolecules to enable active sample concentration, filtering, washing, transport, mixing and other sample handling operations.

Mitigation of biomolecular adsorption with hydrophilic polymer additives

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Orange, CA, United States of America

Peter-Patrick De Guzman