Amo Development, LLC

Abbott Medical Optics Inc.

Advanced Liquid Logic, Inc.

Peter Patrick De Guzman

Zsolt Bor

Michael A Campos

Anthony W Dennison

Chang-Jin Kim

Uichong B Yi

Wayne Po-Wen Liu

Wayne Liu

Systems and methods for locating the center of a lens in the eye are provided. These systems and methods can be used to improve the effectiveness of a wide variety of different ophthalmic procedures. In one embodiment, a system and method is provided for determining the center of eye lens by illuminating the eye with a set of light sources, and measuring the resulting first image of the light sources reflected from an anterior surface of the lens and the resulting second image of the light sources reflected from a posterior surface of the lens. The location of the center of the lens of the eye is then determined using the measurements. In one embodiment, the center of the lens is determined by interpolating between the measures of the images. Such a determination provides an accurate location of the geometric center of the lens.

System and method for eye orientation

Embodiments of this invention generally relate to systems and methods for eye imaging, and more particularly to measuring the size and position of the lens capsule and of the implanted intraocular lens. In one embodiment, a method for measuring the size and position of the lens capsule and of the implanted intraocular lens comprises generating and emitting one or more light beams at an angle adjacent to the eye, generating one or more eye images, and detecting the position and/or boundary of a lens capsule from its shadow casted by reflected light on the iris.

Systems and methods for measuring position and boundary of lens capsule and implanted intraocular lens in eye imaging

A refill droplet facilitates the extraction of a droplet laterally from a channel in a microfluidic apparatus. Such extraction allows a discrete band of separated particles or solute molecules to be excised from a fluid stream and processed and analyzed separately. An extraction point is located along the length of the channel and includes an EWOD surface or similar microfluidic technology to extract a droplet. An opening in the channel opposite the extraction means is equipped with microfluidic technology to transport a refill droplet to the opening. The refill droplet is moved into the channel or column to occupy the area previously occupied by the extracted droplet. This prevents distortion or mixing of the bands of particles or molecules within the channel and prevents the draining of any portion of the fluidic system.

Droplet extraction from a liquid column for on-chip microfluidics

Methods of improving microfluidic assays are disclosed. Assays can be improved (better signal to noise ratio) by using sessile drop evaporation as an analyte concentration step (enhanced signal) and repeated passes of wash droplets as a means to reduce non-specific binding (noise reduction). In addition multiple massively parallel analyses improve the statistical precision of the analyses.

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Orange, CA, United States of America

Peter Patrick De Guzman