Morphosys Ag

Peter Pack

Achim Knappik

Liming Ge

Simon Moroney

Andreas Pl&uuml;ckthun

Andreas Plückthun

Andrei Lupas

Knappik Achim

Ge Liming

Moroney Simon

Pl&uuml;ckthun Andreas

The present invention relates to a method of identifying one or more genes encoding one or more proteins having an optimized property. In particular, the method comprises expressing a collection of genes and screening for a desired property, identifying a plurality of genes having the desired property, and replacing one or more one or more sub-sequences of each of said genes with a different, compatible genetic sub-sequence, and screening again in order to identify genes encoding proteins having an optimized property.

Protein (poly)peptides libraries

The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.

Protein(poly)peptide libraries

Protein/(poly)peptide libraries

The present invention relates to a method for targeted assembly of distinct active peptide or protein domains into a single complex and to such complexes. The invention relates particularly to the fusion of peptide or protein domains to complementary association domains which are derived from a single tertiary or quaternary structure by segmentation. The association domains are designed to assemble in a complementary fashion, thereby providing multifunctional (poly)peptides.

Targeted hetero-association of recombinant proteins to multi-functional complexes

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Munich, Germany

Peter Pack