Merrell Dow Pharmaceuticals

The Dow Chemical Company

Merrell Pharmaceuticals, Inc.

Peter P McCann

Albert Sjoerdsma

Alan J Bitonti

Philippe Bey

Michael L Edwards

David M Stemerick

Chrislyn M Carson

Patrick J Casara

This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of parasitic protozoa.

Polyamine derivatives

Drug-resistant malarial infection in humans can be effectively treated with standard antimalarial agents if administered in conjunction with desipramine.

Despiramine in the treatment of drug-resistant malarial infections

Red blood cells which are infected with the parasite P. falciparum cause the cells to become sticky and less deformable. This results in a build-up of cells on the vascular wall and creates occlusions to blood flow which are thought to cause the cerebral, renal and liver complications of P. falciparum infections. Certain esters of castanospermine prevent or reduce the adhesion of falciparum infected blood cells to the vascular endothelial wall and are a useful adjunct in the treatment of malaria.

Esters of castanospermine in the treatment of cerebral malaria

This invention relates to the use of .alpha.- halomethyl, .alpha.-acetylenic or .alpha.-allenic derivatives of arginine and agmatine, or their dehydro analogs, in the treatment of Chagas disease and Coccidiosis.

Method of inhibiting protozoal growth

This invention relates to a method of controlling phytopathogenic rust and smut fungi of the Uredinales order in a plant locus which comprises applying a fungicidally effective amount of an ornithine decarboxylase inhibitor.

Method of controlling phytopathogenic fungus

.alpha.-Substituted amines and .alpha.-substituted-.alpha.-amino acids are described which are useful in inhibiting the growth of protozoa in animals.

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Lebanon, IN, United States of America

Peter P McCann