Eli Lilly and Company

London Hospital Medical College

Peter P Ho

Jill A Panetta

William B Lacefield

Ken Matsumoto

Quentin F Soper

David R Blake

Nicola Simmonds

David Rampton

Inflammatory bowel disease is treated, and patients are protected from a relapse into active disease, by the administration of a compound chosen from a series of 3-phenyl-5-carboxypyrazoles and isothiazoles.

Treatment of inflammatory bowel disease

A method of inhibiting superoxide release and reducing tissue damage following an inflammatory or ischemic event employing benzothiophenes, benzofurans, and naphthalenes is disclosed.

Method of inhibiting superoxide release

This invention provides a method of treating asthma in mammals which comprises administering an effective amount of Pinacidil.

Antiasthmatic method

This invention provides for pharmaceutical formulations of certain benzothiophene derivatives and a method of using the derivatives or formulations for the treatment of asthma.

Benzothiophene derivatives

Novel triaryl thiazole compounds are useful as analgesic agents. In particular, 2-(4-halophenyl)-4,5-bis(4-methoxyphenyl)thiazoles are used. These compounds are prepared by condensation of a substituted thiobenzamide with a substituted desyl chloride.

2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use

A method of treating inflammation which utilizes topically-active 5,6-diaryl-1,2,4-triazines having the formula, ##STR1## wherein R is hydrogen or --(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are C.sub.1 -C.sub.3 alkoxy or di(C.sub.1 -C.sub.3 alkyl)amino; and the pharmaceutically-acceptable acid addition salts of basic members thereof.

5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents

A method of treating inflammation which utilizes topically-active 5,6-diaryl-1,2,4-triazines having the formula, ##STR1## wherein R is hydrogen or --(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are halo, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or di(C.sub.1 -C.sub.3 alkyl)amino, with the proviso that at least one of R.sub.2 and R.sub.3 is halo or C.sub.1 -C.sub.3 alkyl; and the pharmaceutically-acceptable acid addition salts of basic members thereof.

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Carmel, IN, United States of America

Peter P Ho