The University of Texas System

Multiphase Flow International

Saudi Arabian Oil Company

Peter P Antich

Billy Smith

Edmond Richer

Edward N Tsyganov

Jon A Anderson

Yildirim Hurmuzlu

Ali Dogru

Padmakar V Kulkarni

Charles Y Pak

Charles Y C Pak

Ervin J Fenyves

Robert C Murry, Jr

James E Dowdey

Matthew A Lewis

Robert W Parkey

Ralph P Mason

An apparatus and method to determine fractions of various phases in a multiphase fluid. The apparatus includes main body including an interior configured receive a multiphase fluid and an exterior. The apparatus senses fluid pressure of multiphase fluid received in the interior and senses a fluid temperature of the multiphase fluid. The apparatus transmits an ultrasonic wave into the fluid and detects the transmitted wave to determine its velocity and attenuation. The apparatus may adjust the determined velocity and attenuation based on the temperature and pressure of the fluid to compensate for a difference between the sensed temperature and pressure and a standard temperature and pressure. The apparatus determines a gas fraction, water fraction, and a non-water fluid fraction of the multiphase fluid based on the sensed fluid pressure, the sensed fluid temperature, and the velocity and attenuation of the ultrasonic wave in the multiphase fluid.

Ultrasound multiphase fraction meter and method for determining phase fractions in a multiphase fluid

The present invention is an apparatus, method and system for determining the coefficient of elasticity of a target by detecting determining simultaneously two or more critical-angle reflections of an ultrasound wave from the target using an ultrasound transducer that includes a transmitter and two or more receivers and calculating the elasticity coefficients of the target.

Rapid and accurate detection of bone quality using ultrasound critical angle reflectometry

A novel use of a solid state light detector with a low impedance substrate is described. Light that enters the substrate after traversing the antireflective layer creates an electron-hole pair. The electrons are collected in a crystalline epitaxial layer that spans the space charge region, or depletion layer. A high electric field accelerates free electrons inside the depletion region. The electrons collide with the lattice to free more holes and electrons resulting from the presence of a n-p junction, or diode. The diode is formed by placing the crystalline layer which has positive doping in close proximity with the electrodes which have negative doping. The continual generation of charge carriers results in avalanche multiplication with a large multiplication coefficient. During the avalanche process, electrons can be collected enabling light detection. A resistive layer is used to quench, or stop, the avalanche process.

Method of using a wide wavelength range high efficiency avalanche light detector with negative feedback

A novel use of a solid state light detector with a low impedance substrate is described. Light that enters the substrate after traversing the antireflective layer creates an electron-hole pair. The electrons are collected in a crystalline epitaxial layer that spans the space charge region, or depletion layer. A high electric field accelerates free electrons inside the depletion region. The electrons collide with the lattice to free more holes and electrons resulting from the presence of an n-p junction, or diode. The diode is formed by placing the crystalline layer which has positive doping in close proximity with the electrodes which have negative doping. The continual generation of charge carriers results in avalanche multiplication with a large multiplication coefficient. During the avalanche process, electrons can be collected enabling light detection. A resistive layer is used to quench, or stop, the avalanche process.

Wide wavelength range high efficiency avalanche light detector with negative feedback

The disclosed invention includes an apparatus and method for detecting radiation in a detector. The radiation to be detected ionizes the atoms in the intrinsic silicon lattice of the detector to produce a small signal of freed elections. The small signal is then amplified by avalanche multiplication in a self-limiting manner by preventing the amplified electrons from traveling through a resistive layer, thereby reducing the electric field to limit the avalanche multiplication. An imaging system incorporating the new detector design is also disclosed.

Semiconductor radiation detectors with intrinsic avalanche

Wide wavelength range high efficiency avalanche light detector with

Apparatus for generating a high contrast image of a living subject includes an X-ray source capable of generating an X-ray beam having an energy between about 4 MeV and about 40 MeV, means for directing the X-ray beam generated by the X-ray source to a preselected area of the body of a living subject, and at least one scintillating detector capable of detecting photons which are generated as a result of the interaction of the X-ray beam with the body of the living subject.

Megavoltage scanning imager and method for its use

.sup.19 F labelled antibodies are disclosed which are useful in methods of NMR imaging and spectroscopy. The compositions comprise a .sup.19 F-containing sensor moiety and an antibody, preferably a monoclonal antibody, and can optionally also comprise a spacer moiety to separate the sensor moiety and the antibody.

.sup.19 F labelled antibodies and fragments thereof as NMR imaging and

Oxygen tension of tissue in a living subject may be determined non-invasively by a method which involves: administering to a living mammalian subject a biologically compatible perfluorocarbon emulsion in an amount effective to generate a measurable .sup.19 F spectrum under .sup.19 F NMR spectroscopy; allowing sufficient time to elapse for substantially all of the perfluorocarbon emulsion to be cleared from the vascular system of the subject, with a portion of the perfluorocarbon emulsion becoming sequestered in tissue of the subject; subjecting the tissue in which the perfluorocarbon emulsion has become sequestered to a .sup.19 F magnetic resonance spectroscopy procedure in which simultaneous measurements are made of spin-lattice relaxation rates for at least two separate resonances of the perfluorocarbon emulsion; and comparing the at least two spin-lattice relaxation rates measured in the .sup.19 F magnetic resonance spectroscopy procedure to a predetermined relation of spin-lattice relaxation rate to oxygen tension and temperature for the perfluorocarbon emulsion used, and thereby determining the oxygen tension and temperature of the tissue.

Use of .sup.19 F magnetic resonance to non-invasively assess pO.sub.2

An apparatus and method are disclosed for detecting and locating the origin of a gamma ray in a medical diagnostic imaging system. At least one primary fiber, which is a scintillating optical fiber, is positioned to receive radiation from a gamma ray source. At least one secondary fiber intersects the primary fiber at a non-zero angle. Both fibers have a core surrounded by a cladding, with the claddings of the two fibers in optical contact at an intersection point. Both the primary and secondary fibers are provided with means for detecting light propagated in the fibers. The interaction of radiation such as a gamma ray with the primary fiber will result in the propagation of light in both the primary and secondary fibers, thereby permitting the determination of the site of impact of the gamma ray in the detector, and possibly also enabling the determination of the path of incidence of the gamma ray.

Position sensitive radiation detector

An apparatus and method are disclosed for detecting and locating the origin of a gamma ray in a medical diagnostic imaging system. At least one primary fiber, which is a scintillating optical fiber, is positioned to receive radiation from a gamma ray source. At least one secondary fiber intersects the primary fiber at a non-zero angle and is in optical contact with the primary fiber. Both the primary and secondary fibers are provided with means for detecting light propagated in the fibers. The interaction of a gamma ray with the primary fiber will result in the propagation of light in both the primary and secondary fibers, thereby permitting the determination of the site of impact of the gamma ray in the detector, and possibly also enabling the determination of the path of incidence of the gamma ray.

Position sensitive gamma ray detector

.sup.19 F labelled compounds are disclosed which are useful in methods of NMR imaging and spectroscopy. The compounds comprise a .sup.19 F-containing sensor moiety, and a transport polymer or substrate, and can optionally also comprise a spacer moiety to separate the sensor moiety and the transport polymer.

19F labelled dextrans and antibodies as NMR imaging and spectroscopy

The invention involves a treatment process for improving the intrinsic quality of bone in osteoporotic patients. This can reduce the frequency of spinal fractures by inducing formation of bone which is mechanically stronger than that which it replaces. The process preferably comprises: administering an enteral form of sodium fluoride to maintain an individual's serum fluoride level from about 100 to about 200 ng/ml with a circadian fluctuation of less than about 75 ng/ml, and dietarily supplementing said individual with absorbable calcium (preferably calcium citrate). In one embodiment, sodium fluoride administration is interrupted temporarily (for about 30 to about 60 days in a 13 or 14 month cycle) to prevent loss of fluoride effectiveness and avert impaired mineralization of bone. Calcium is preferably maintained by an enteral dose of about 400 mg calcium twice daily. A vitamin D preparation may also be administered to the individual to further enhance bone strengthening. As a method for assessing response, periodic noninvasive in vivo measurements of intrinsic bone quality are made by reflection ultrasound, and the treatment regimen is maintained, altered or discontinued based on clinical assessment of the results. In this way, clinical response to the treatment is evaluated to guide its continued application.

Growing community of inventors

Richardson, TX, United States of America

Peter P Antich