Bayer Aktiengesellschaft

Miles Laboratories, Inc.

Miles Inc.

Peter Norman

Ulrich Rosentreter

Trevor S Abram

Hilary P Francis

Nigel J Cuthbert

Elisabeth Perzborn

Ulrich E Muller

Erwin Bischoff

Volker-Bernd Fiedler

Marie G McKenniff

Joachim Hutter

Harold C Kluender

Steven R Tudhope

Horst Boshagen

Heinrich Meier

Ulrich Niewohner

Phillip J Gardiner

Graham Holmwood

Franz-Peter Hoever

Hans-Georg Dellweg

Stephen Richard Tudhope

Gabriele Braunlich

Brian T Warren

Robert N Schut

Stephen R Tudhope

John E Ransohoff

Tudhope Stephen R

Horst Bohagen

Graham A Place

Roderick L Hall

Warren, Brian T

The invention relates to benzoic acid derivatives being leukotriene antagonists. The compounds therefore are suitable as active ingredients in medicaments particularly in medicaments for the treatment of respiratory diseases.

Leukotriene antagonistic benzoic acid derivatives

The invention relates to the use of substituted cyclopentane-diones and cyclopentane-triones for the preparation of medicaments which as chloride channel blockers are suitable for controlling airway diseases, secretory diarrhea and inflammatory diseases.

Use of substituted cyclopentane- di- and -triones

Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,

Antithrombotic substituted cycloalkano (B) dihydroindole sulphonamides

Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I ##STR1## in which X is --S--,

Aryl alkenoic acid derivatives as leukotriene antagonists

Iso- and heterocyclic phenylsulphonamides can be prepared by reaction of corresponding iso- and heterocyclic amines with phenylsulphonic acid derivatives. The iso- and heterocyclic phenylsulphonamides have thrombocyte aggregation-inhibiting and thromboxane A.sub.2 antagonist action and can be used in medicaments.

Antithrombotic iso- and heterocyclic phenylsulphonamides

The new substituted alkenoic acid derivatives can be prepared by reacting the appropriate aldehyde with a phosphonium compound. The compounds have leukotriene antagonistic properties and can be incorporated into pharmaceutical compositions.

Substituted alkenoic acid and its derivatives

An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH.sub.2 --, or oxygen or a direct bond,

Alkenoic acid derivatives

New cycloalkano[b]dihydroindoles and -indolesulphonamides, substituted by heterocycles, of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and

Cycloalkano(b)dihydroindoles and -indolesulphonamides substituted by

Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,

Antithrombotic substituted cycloalkano(b)dihydroindole- and

Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,

Antithrombotic substituted cycloalkano(B)dihydroindole- and

Disclosed are trisubstituted benzene derivatives of the formula ##STR1## wherein B is selected from the group consisting of --NHCOC(CH.sub.3).sub.3, 1,3-oxazolinyl and --CONHR, wherein R is methyl, phenyl, or t-butyl; Y is selected from the group consisting of CO.sub.2 H, CHO, CO.sub.2 R' and COR', wherein R' is a lower alkyl having from 1 to 4 carbon atoms; and A is H or tetrahydropyran. Said compounds are valuable intermediates in the preparation of certain anti-allergic chromone or thiochromone-5-oxamic acid derivatives.

Trisubstituted benzene derivatives and a method for the preparation

Certain 5-substituted chromones and thiochromones and pharmacologically acceptable salts thereof are disclosed. The compounds possess antiallergic properties and are represented by the formula: ##STR1## wherein: X is selected from the group consisting of --O--, --S--, and --SO.sub.2 --;

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Slough, United Kingdom

Peter Norman