Micromass UK Limited

Peter Nixon

John Brian Hoyes

Richard Denny

Jason Lee Wildgoose

Martin Raymond Green

Keith George Richardson

Richard Chapman

A method of correcting mass spectral data comprises making calibration measurements of first intrinsic components (A, B, C) at one or more calibration times (t1) using calibrants which have known mass to charge ratio (m/z) values or previously mass measured mass to charge ratio (m/z) values, making a list of second intrinsic components (D, E, F) which are present during more than one acquisition periods, wherein the second intrinsic components have mass to charge ratio (m/z) values that were not present or observed during or close to the one or more calibration times (t1) but which do overlap in time with the first intrinsic components (A, B, C), and utilising the list to calculate a mass or mass to charge ratio (m/z) correction factor for one or more acquisition periods which are not close or adjacent in time to an acquisition period containing a directly calibrated mass to charge ratio (m/z) value.

Adaptive intrinsic lock mass correction

A method of mass spectrometry is disclosed comprising passing ions to an oversampled Time of Flight mass analyser () and sequentially recording ion signals on a plurality of different channels () to obtain a plurality of first oversampled mass spectral data sets of reduced complexity. An upstream separation device () may be provided to further reduce the complexity of each of the mass spectral data sets.

Oversampled time of flight mass spectrometry

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Winsford, United Kingdom

Peter Nixon