Astrazeneca Ab

Karin & Sten Mortstedt Cbd Solutions Ab

Peter Nilsson

Erik Ringberg

Magnus Munck Af Rosenschöld

Grigorios Nikitidis

Antonios Nikitidis

Petra Johannesson

Christian Tyrchan

Carl Jonas Lindh

Hanna Birgitta Ellinor Andersson

Wesley Ralph Schaal

Hamid Shirani

The invention provides compounds of formula (I) and compositions comprising compounds of formula (I). The invention further provides uses of the compounds of formula (I) and compositions comprising compounds of formula (I), including the use of such compounds for the detection of tau deposits, and the use of such compounds and compositions as diagnostic agents in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease or corticobasal degeneration, or for the prevention or treatment of a disease or disorder such as Alzheimer's disease or corticobasal degeneration. 

Selective ligands for tau aggregates

There is provided compounds of formula I, wherein E, E, E, E, L, Y, Y, Y, Rand z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene Csynthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.

Compounds and uses

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Stockholm, Sweden

Peter Nilsson