Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw

Peter Marijnen

Judith Dierlamm

Mathijs Baens

Methods for determining whether a tissue sample or an analogue and/or derivative thereof comprises a cell with a chromosome (11:18) translocation associated with malignancies such as mucosa-associated lymphoid tissue (MALT) lymphomas. The invention further provides insight into a novel mechanism of transformation of primary cells. The mechanism involves expression of a fusion proteinaceous molecule comprising at least apoptosis inhibitor 2 (API2) or a functional part, derivative and/or analogue thereof fused to at least one other proteinaceous molecule. The invention also provides a novel nucleic acid sequence and proteinaceous molecule expressed from the sequence termed 'MALT-lymphoma associated Translocation (MLT) protein.'

Molecular characterization of chromosome translocation t(11;18)(q21;q21) and its correlation to carcinogenesis

Methods for determining whether a tissue sample or an analogue and/or derivative thereof comprises a cell with a chromosome &lcub;11:18&rcub; translocation associated with malignancies such as mucosa-associated lymphoid tissue (MALT) lymphoma's. The invention further provides insight into a novel mechanism of transformation of primary cells. The mechanism involving expression of a fusion proteinaceous molecule comprising at least apoptosis inhibitor 2 (API2) or a functional part, derivative and/or analogue thereof fused to at least one other proteinaceous molecule. The invention also provides a novel nucleic acid sequence and proteinaceous molecule expressed from the sequence termed MALT-lymphoma associated Translocation (MLT) protein.

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Herent, Belgium

Peter Marijnen