Marengo Therapeutics, Inc.

Peter Marek

Andreas Loew

Brian Edward Vash

Madan Katragadda

Jonathan Hsu

Stephanie J Maiocco

Seng-Lai Tan

Nidhi Malhotra

Gurkan Guntas

Multifunctional molecules that include i) an antigen binding domain that binds to a T cell receptor beta chain constant domain 1 or T cell receptor beta chain constant domain 2; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; (iv) a death receptor signal enhancer; and/or (v) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Multifunctional molecules that bind to T cell related cancer cells and uses thereof

Growing community of inventors

Hudson, MA, United States of America

Peter Marek