Sri International

Peter Madrid

Nathan Collins

Jeremiah Malerich

Michal Avital-Shmilovici

Pauline Bourbon

Kenneth J Ryan

Gary A Koolpe

Sidharth Chopra

Thomas Shaler

Markus Krummenacker

Bryan Glaser

Mario Latendresse

Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. An example method includes using logic circuitry to: select a plurality of molecules that include a plurality of subgroups, each of the plurality of molecules exhibiting a mass spectrometry characteristic that is distinguishable from mass spectrometry characteristics of other molecules of the plurality, and assign the plurality of molecules with a position in a sequence of a plurality of synthetic compounds forming a library. The method further includes defining, as data in a memory circuit of the logic circuitry, the plurality of synthetic compounds that are sequenceable via mass spectrometry using the assigned positions of the plurality of molecules for communicating to other circuitry for formation thereof via coupling chemistry or screening of a particular function.

Mass spectrometry distinguishable synthetic compounds, libraries, and methods thereof

Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

Computational generation of chemical synthesis routes and methods

Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. A polymer bead, in accordance with embodiments, has an interior surface and an exterior surface that are topologically segregated from one another. The interior surface includes a protecting group and the exterior surface includes a deprotected group, which can also be referred to as a deprotected functional group. The protecting group can includes a nitrobenzenesulfonamide group that protects an amine group.

Topologically segregated polymer beads and methods thereof

Benzotriazine doxides are disclosed as drugs targeting, including novel compounds of formula I: 

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An aminocoumarin conjugated to a fluorescent label through a secondary amine, is operative as a fluorescent polarization probe of the DNA gyrase B or topoisomerase IV E subunit. The probe is used for detecting topoisomerase inhibitor binding by fluorescence polarization, particularly in a high-through put topoisomerase inhibitor assay.

Growing community of inventors

Sunnyvale, CA, United States of America

Peter Madrid