Other

Panvera LLC

Merck Sharp + Dohme Corp.

Beijing Genomics Institute at Shenzhen

Peter M Shaw

Michael G Hellmann

Xun Xu

David V Thompson

Devan V Mehrotra

Junhua Li

Olga Trubetskoy

Rebecca L Blanchard

Robin Mogg

Mary Beth Dorr

Judong Shen

The present invention provides genetic markers on human chromosome 6 that are associated with a beneficial response to a treatment that targets() toxin B (TcdB), e.g. a TcdB antibody. These TcdB treatment response markers are useful, inter alia, to identify patients who are most likely to benefit from treatment that targets TcdB in methods of treating patients having a disease susceptible to treatment with a TcdB antibody, and in methods for selecting the most appropriate therapy for such patients. The invention also provides antibodies, drug products, and kits useful with the TcdB Treatment response markers of the invention.

Human genetic markers associated with response to treatments that target clostridium difficile toxin B

A device and method are provided for protecting the inside of a microwave oven from food splattering during cooking. The device is made of breathable food grade paper, is a truncated cone in shape with a pleated side wall for rigidity and at least one reinforcing structure on a top surface. Top surface reinforcement may be one or more folded paper reinforcement bars or folded paper reinforcement members, shaped as circles, squares, or any other convenient shape. Reinforcement bars may be radial across the top surface or nonradial, and may be linear or curvilinear. The food shield device is made by conventional paper die stamping methods.

Disposable microwave food shield

A disposable microwave food shield for preventing splatter of food onto the interior surfaces of microwave ovens made from absorbent, yet rigid paper material.

A process used to identify activity of conjugative enzymes involved in xenobiotic transformations, such as glucuronosyltransferases.

Process for glucuronidation screening

A storable biotransformation mixture that can oxidize a drug, comprising a cytochrome P450 enzyme, an electron donor; and, a buffer solution. In a preferred embodiment the mixture also contains liposomes, cytochrome b.sub.5 and NADPH-P450 reductase as the electron donor. The mixture is storable at a temperature less than 8.degree. C. to for at least two weeks and is able to oxidize a drug after storage.

Growing community of inventors

Yardley, PA, United States of America

Peter M Shaw