3M Innovative Properties Company

Peter M Seiler

Scott A Burton

Steven C Stickels

Babu Nana Gaddam

Kevin Michael Lewandowski

Duane Douglas Fansler

Ahmed Salih Abuelyaman

George F Vesley

Maureen Ann Kavanagh

James S Stefely

Stephen E Krampe

Gary W Maier

John T Capecchi

Paul Hattam

Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula &#x2014;[O&#x2014;R&#x2014;C(O)]&#x2014; wherein: 'R' is a linear, branched, or cyclic organic group, 'n' is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.

Medicinal compositions and method for the preparation thereof

A gel material and medical articles including such material, wherein the transparent gel material includes a polymerized poly(alkylene oxide) macromonomer that, prior to polymerization, is free-radically polymerizable, multifunctional (preferably difunctional), and has an average molecular weight of at least about 2000.

Gel materials, medical articles, and methods

The present invention provides methods of manufacturing a viscoelastic article by a process that includes coating a release surface with a curable composition and then curing the composition to form the viscoelastic article. Viscoelastic articles manufactured according to the methods of the present may be constructed to be self-supporting.

Method of making a viscoelastic article by coating and curing on a reusable surface

An absorbent dressing comprising a hydrophilic gel absorbent layer having a patterned surface on at least one major surface thereof is provided. The patterned surface allows greater surface area for absorption of wound exudate when oriented toward the wound surface, while reducing the absorbent surface area in direct or indirect contact with the wound.

Patterned absorbent article for wound dressing

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Minneapolis, MN, United States of America

Peter M Seiler