Beecham Group Plc

Peter M Newsome

Lee James Beeley

Noel A Mullan

Stephen F Moss

John P Marshall

Geoffrey H Baker

Noel A Mullen

Malcolm N Burgess

Compounds of formula (I): ##STR1## or a salt or acyl derivative thereof; wherein

Benzylideneamino- and phenylacetylguanidines and their pharmaceutical

A compound of formula (I): ##STR1## or a salt thereof wherein R.sup.1 is halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy

Amidines

Compounds of formula (I) ##STR1## and acid addition salts thereof, wherein R.sup.1 is hydrogen, hydroxy, alkoxy, aryloxy, aralkoxy, heteroaryloxy or heteroaralkoxy; and

5,6,7,8-tetrahydro-napthonitrile intermediates

Compounds A--B--C wherein A is 2 imidazolinyl or N-alkyl derivative thereof, B is oxygen, sulphur, CR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 are hydrogen or alkyl, or NR.sup.3 wherein R.sup.3 is hydrogen or alkyl, and C is a 5- or 6- membered carbo- or heterocyclic group having a nitrogen containing substituent and up to two other substituents, are useful in treatment of diarrhoea or scours. Certain compounds A--B--C are novel.

Treatment of diarrhoea with 2-aminoimidazoline derivatives

Compounds of formula (I) ##STR1## and acid addition salts thereof, wherein

Amidine derivatives

Vasoconstrictor .alpha.-adrenergic agonists of formula (I)

Treatment of diarrhoea

Compounds of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from halogen, alkyl, haloalkyl, alkoxy and alkoxyalkyl,

Quaternary amino imidazolidines, compositions and use

Compounds A - B - C wherein A is 2 imidazolinyl or N-alkyl derivative thereof, B is oxygen, sulphur, CR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 are hydrogen or alkyl, or NR.sup.3 wherein R.sup.3 is hydrogen or alkyl, and C is a 5 - or 6 - membered carbo- or heterocyclic group having a nitrogen containing substituent and up to two other substituents, are useful in treatment of diarrhoea or scours. Certain compounds A - B - C are novel.

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Cheam, United Kingdom

Peter M Newsome