Schering Corporation

Merck Sharp + Dohme Corp.

Peter M Ihnat

Sydney O Ugwu

Vinay Radhakrishnan

Leonore Catherine Witchey-Lakshmanan

Varda E Sandweiss

Lenore C Witchey-Lakshmanan

Pui-Ho C Yuen

Gary J Vellekamp

Andreas Frei

Laureano L Bondoc, Jr

Henry K H Kwan

Frederick William Iv Porter

Henry KH Kwan

Varda Sandweiss

Henry Kwan

John Chu-Tay Tang

Pui-Ho Yuen

Disclosed are aqueous and lyophilized formulations containing SYN3 and methods of their use for treating bladder cancer.

SYN3 compositions and methods

In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine or mixtures thereof; a lyophilized powder comprising said pharmaceutical formulation, and articles of manufacture thereof.

Processes of making and using pharmaceutical formulations of antineoplastic agents

Processes of making pharmaceutical formulations of antineoplastic agents

Pharmaceutical formulations of antineoplastic agents

Pharmaceutical formulations of antineoplastic agents and processes of making and using the same

A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2&deg; C. to 27&deg; C. Methods for concentrating and purifying virus preparations are also disclosed.

Compostions comprising viruses and methods for concentrating virus preparations

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Brooklyn, NY, United States of America

Peter M Ihnat