University of California

Peter M Clark

Michael E Jung

Owen N Witte

David A Nathanson

Nikolai M Evdokimov

Timothy F Cloughesy

Blanca Graciela Flores Castillo

Lorenz Urner

Jonathan Tsang

Gyudong Kim

The present disclosure relates to compounds, compositions and methods for treating cancer, including compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating cancer in the brain, including glioblastoma and other EGFR mediated cancers. The disclosure further relates to methods of treating cancers such as glioblastoma and other EGFR mediated cancers that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.

Compositions and methods for treating cancer

The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.

Positron emission tomography probe to monitor selected sugar metabolism in vivo

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Los Angeles, CA, United States of America

Peter M Clark