Pierre Fabre Medicament

Peter Lowe

Jean-François Haeuw

Cédric Bes

Nicolas Boute

Marie-Claire Janin-Bussat

Martine Malissard

Juliette Trepreau

Céline Bertaux

Sven Berger

Alicia Contet

Barbara Akla

Cedric Bes

The present invention relates to new immunocytokines which are useful for the treatment of cancer. These fusion proteins comprise (i) an antibody or antigen-binding fragment thereof fused to (ii) a cleavable peptide linker, and (iii) cytokine, or functional fragments thereof. Methods of treatment using these immunocytokines are also disclosed.

Immunocytokines for the treatment of cancer

The invention relates to a method for generating a DNA sequence coding for the heavy chain or the light chain of at least one antibody from RNA from a cell capable of producing an antibody. More particularly, the invention relates to the generation of a monoclonal antibody library. The invention also relates to the use of an antibody library for screening monoclonal antibodies, preferably human antibodies for treating cancer.

Method for generating and screening an antibody library

The invention relates to a minimized phage display vector comprising at least a cloning cassette, a phage display cassette and a bacterial cassette, said cloning cassette comprising a nucleic acid sequence encoding a polypeptide corresponding at least to the intra-domain loop of a constant domain of an antibody. It also relates to their uses for the production of libraries of phages, each phage expressing on its surface a binding protein to be screened for its capacity to bind a binding partner.

Phage display vector

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Droisy, France

Peter Lowe