Vertex Pharmaceuticals, Inc.

Peter Littlewood

Philip Michael Reaper

Scott Fields

John Robert Pollard

Mohammed Asmal

Scott Zachary Fields

Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein. 

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Abingdon, United Kingdom

Peter Littlewood