Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

N-gene Research Laboratories, Inc.

N-gene Research Laboratiories Inc.

Peter Literati Nagy

Kalman Takacs

Antal Simay

Gabor Kovacs

Gyula Sebestyen

Istvan Stadler

Gyula Papp

Laszlo Szekeres

Ilona Kiss Nee Ajzert

Ilona K Ajzert

Maria Hetyey Nee Papp

Marian E Puskas

Maria H Papp

Zoltan Sumeghy

Marian Ecsery Nee Puskas

Sandor Viragh

Eva Udvardy

The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suitable for the treatment of a state connected with oxygen deficit and/or energy deficit, or a disease based on PARP inhibition, especially an autoimmune or neurodegenerative disease, and/or a viral disease, and/or a disease caused by a toxic effect.

Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same

The invention concerns new sulfur-containing isoquinoline derivatives. More particularly, the invention relates to isoquinoline derivatives of the general formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,

Sulfur-containing isoquinoline derivatives in pharmaceutical

The invention concerns new compounds of the formula (I) ##STR1## wherein R.sup.1 is hydrogen, phenyl or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro;

1,2,4-Oxadiazolin-5-one derivatives, process for their preparation and

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Budapest, Hungary

Peter Literati Nagy