K.d. Pharma Gmbh

K.d. Pharma Bexbach Gmbh

Peter Lembke

Rudolf Krumbholz

Norbert Schirra

Heinz Engelhardt

Karin Krumbholz

Christine Krumbholz

A process for extracting a substance or a substance group from a mixture utilizes a solvent for separation. The mixture is treated with the solvent in the presence of a sorbent as the stationary phase, wherein the solvent is conducted past the sorbent in a co-current flow with the mixture or in a counter-current flow against the mixture, or wherein the solvent is conducted past the non-moving mixture and the sorbent. The solvent and the sorbent are selected such that the holding effect of the sorbent supports the separation by the solvent during the separation procedure and/or subsequently supplements the separation by interacting with the solvent as the mobile phase.

Process for extracting a substance or a substance group from a mixture

Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and 'reversed phase' phases, the former in turn chosen from the group consisting of RP18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure and/or temperature gradient is applied to the chromatographic column during the elution of the target fatty acid or derivative thereof.

Cromatography process for recovering a substance or a group of substances from a mixture

A urea-containing component of a skin care agent or skin preparation, wherein the urea forms inclusion compounds with fatty acids and/or fatty acid compounds, so that fat is made available for skin care which is protected against oxidation. A method of manufacturing the urea-containing component of a skin care agent includes cooking an oil or a mixture of fatty acid ethyl esters manufactured from an oil with urea in a solvent in a non-oxidizing atmosphere until the urea has been dissolved, permitting the mixture to cool, and finally cooling the mixture to a final temperature of below 10.degree. C. and separating the resulting precipitate.

Component of a skin care agent

A method for recovering at least one unsaturated fatty acid having sixteen or more carbon atoms and/or at least one compound of such a fatty acid from a mixture derived from vegetable, animal or marine sources is provided. Fatty acids and/or fatty acid compounds of the mixture, in free acid or esterified form, are passed into a mobile phase of liquid carbon dioxide in a column over a stationary phase. The stationary phase contains a support and a material bound to the support which contains at least one free electron pair and/or multiple bond. After eluting any saturated fatty acid or fatty acid compound of the same number of carbon atoms from the column, the unsaturated fatty acid and/or fatty acid compound is recovered in pure chemical form or as an enriched mixture.

Growing community of inventors

Gersheim-Herbitzheim, Germany

Peter Lembke