Sqi Diagnostics Systems Inc.

Spectral Diagnostics, Inc.

Umedik, Inc.

Rust-oleum Corporation

Biophys, Inc.

Siamons International Inc.

Peter Lea

Philip L Poissant

Mingfu Ling

Jennifer Hansen

Al Siamon

Thomas Ewart

Brian Bacik

Stuart X Carmichael

Claude Ricks

Thomas G Ewart

Kate Smith

Rasho Petrovic

Nisar Shaikh

Ladi Sujar

Jeff Hastie

Michelle Gal

Nicole Szabados Haynes

Jun Liu

Domenica De Leo

An adapter receives two separate fluids from a container having two separate fluid compartments and combines the fluids into a single fluid stream for delivery to a spray fluid dispenser. The adapter comprises a unitary housing having a first open end for fluid connection to the container and a second open end for fluid connection to the spray fluid dispenser. The housing defines a manifold forming a fluid passageway therein between the first end and the second end. The manifold includes two separate first conduits formed at the first end. Each of the first conduits is connected to a respective one of the fluid compartments. The manifold further includes a second conduit in fluid communication with the second end for delivery of the combined fluids to the spray fluid dispenser. The first conduits are each in fluid communication with the second conduit.

Dual compartment container adapter

The present invention provides a method of making an assay device for conducting an assay to detect a concentration of an analyte in a sample fluid. The assay devices would typically have a substantially planar surface having a series of site specific immobilized calibration spot arrays containing pre-determined quantities of the analyte printed thereon. In addition, a series of site specific immobilized test spot arrays, including capture antibody for binding the analyte protein is printed on the assay device. The method involves first modifying the planar surface to provide hydrophobic binding sites, hydrophilic linking and covalent bonding sites. Then the method requires printing the series of site specific immobilized test spot arrays and the series of site specific immobilized calibration spot arrays on the substantially planar surface. Applying the sample fluid to the assay device is the next step followed by testing a sensitivity of the assay and modulating ratios of the hydrophobic, hydrophilic and covalent binding sites in order to optimize the sensitivity of the assay.

Method and device to optimize analyte and antibody substrate binding by least energy adsorption

The present invention relates to multiplex microarrays and methods for the quantification of analytes. In particular, the invention relates to improved methods which standardize a target analyte concentration in a test sample against a reference standardization curve derived from validated, approved and recognized reference standards for the target analyte of known concentrations. The present invention also relates to methods and checks for simultaneous measurement of confidence confirming normalization standards and controls.

Analyte quantification multiplex microarrays combining internal and external calibration

The present invention provides a method for fluorescence intensity equalization. The method involves providing an assay device having at least one immobilized array of molecular probes that bind to an analyte bound to a fluorescent marker; providing drying apparatus comprising an aspiration tube having open first and second ends, the second end of the aspiration tube being connected a vacuum source for applying a vacuum through said tube; placing the first end of the aspiration tube in proximity of said at least one immobilized array of molecular probes; and applying a vacuum through said aspiration tube for removing vapor from said at least one immobilized array of molecular probes. The application of the present invention provides for more reliable fluorescent signal intensity readings due to a reduction in signal quenching factors.

Array fluorescence equalization method

The present invention relates to a method and device for the removal of fluids and vapors in containment, from adjacent surfaces including supporting flat surfaces and substrates, such as protein spots printed in arrays and micro-array formats. This method and device removes fluids and vapors under controlled and repeatable conditions, enabling uniform phases for degree of drying incurred by objects, specimen and structures, including tissues, adsorbed particles and biological substrates, while reducing and preventing impact of meniscus phase surface tension forces.

Method and device to remove fluid and vapor

Embodiments of the present invention relate to a three dimensional matrix of selected, synthetic peptide mimic sequences that are preferentially recognized by auto-antibodies, specifically by autoimmune antibodies, to be detected in patients afflicted with rheumatic arthritis, enabling enhanced sensitivity and specificity in detection of these antibodies in pre-symptomatic patients, in patients showing symptoms as well as patients confirmed positive for rheumatoid arthritis.

Synthetic peptides immuno-reactive with rheumatoid arthritis auto-antibodies

The present invention discloses a method for preparing a substrate coated support for use in micro-array devices. The method of the present invention comprises the steps of applying a first coat of substrate to a support, making the substrate coating ramp by subjecting the coated support to centripetal forces, adding a second coat of substrate to the resulting support having a ramping planar coat and subjecting the coated support to centripetal forces for a second time to produce a substrate coated membrane in which the thickness of the substrate layer is uniform across the entire coated surface.

Method for double-dip substrate spin optimization of coated micro array supports

Drying device

Assay device

A method is provided for sterilizing fluids using bolus dosing of a fluid, stretching of the bolus of fluid into a membrane, such as a thin or ultra-thin film, and subsequent irradiation of the individual fluid membranes which are then recollected after sterilization. A system is provided whereby a fluid moves along a defined pathway in traditional bolus flow where each bolus of fluid is interspersed with a bolus of gas. The bolus of fluid, for example from a patient or other sample, moves along the flow path and the width of the flow path is gradually increased until the fluid bolus is stretched (without breaking) to form a thin fluid membrane which can be completely panned using irradiation (such as ultraviolet irradiation) to sterilize the each bolus which has been stretched into a membrane. After sterilization the width of the flow path is gradually narrowed to a sufficient sized such that the bolus returns to a sufficient size to be collected, typically when it forms a small droplet. The collected portions are recombined thereby rendering the original fluid sample completely sterilized for subsequent reintroduction into a patient or other use.

Method and apparatus for flowing sterile ultra-thin fluid membranes

A device and method for separating a fluid component from a non-fluid component of a sample comprises a plurality of microspheres disposed in abutting relation and forming therebetween a plurality of capillary channels, whereby when the microspheres are disposed in fluid communication with a sample the fluid component is separated from the non-fluid component by capillary flow of the fluid component through the capillary channels formed by the interstitial spacing between abutting microspheres.

Device and method for analyzing a biologic sample

Immunoassay test kit with funnel

A cultured, full-thickness integument substitute is disclosed which can be implanted in a patient suffering from severe burns, for example; and consists of a three-dimensional matrix membrane with essentially two surfaces because the length and width are substantially greater than the thickness; the membrane has pores in the area of a first surface thereof which are directly connected to but substantially larger on average than those in the area of the opposite surface of the membrane, and those pores have immobilized within them cells and components of the dermal layer of the integument; the membrane has pores in the area of a second surface thereof which are directly connected to but substantially smaller on average than those in the area of the opposite surface of the membrane, and those pores have immobilized within them cells and components of the epidermal layer of the integument; the membrane also has a lateral pore structure in its internal space which interconnects those pores which pass from one surface to the other of the membrane, permitting co-planar flow of a liquid or suspension through the membrane.

Cultured, full-thickness integument substitutes based on

A medical diagnostic test kit includes a rectangular flat bottom member having an external raised flange and an internal raised flange forming a cavity therein; an elongated dry chemistry membrane held within the cavity; an arcuate cover member secured to the bottom member with the membrane therebetween; and a funnel assembly comprising a funnel member removably attached to the cover member with its nozzle portion extending into a sample opening in the cover member.

Growing community of inventors

Toronto, Canada

Peter Lea