Smithkline Beecham Corporation

Peter Lawrence DeMarsh

Kyung Oh Johanson

Thomas Joseph Carr

Susan B Dillon

Gary Woodnutt

Geoffrey Bainbridge Dreyer

Ashley Edward Fenwick

This invention relates to a method for the prophylaxis of or reducing the severity of post-viral bacterial infection by administering a PDE 4-specific inhibitor prior to or during the course of a viral infection or thereafter during the course of the bacterial infection.

Use of PDE 4-specific inhibitors to reduce the severity of a bacterial infection after a respiratory viral infection

The invention relates to the method of preventing and treating sepsis using chemokines selected from mature or modified KC &lsqb;SEQ ID NO: 1&rsqb;, gro&agr;&lsqb;SEQ ID NO:2&rsqb;, gro&bgr;&lsqb;SEQ ID NO: 3&rsqb; or gro&ggr;&lsqb;SEQ ID NO: 4&rsqb; or multimers thereof, alone or in conjunction with an anti-infective agent. This invention also relates to a new gro&bgr; dimer chemokine.

Dimeric modified gro&bgr; protein

The invention relates to the method of preventing and treating sepsis using chemokines selected from mature or modified KC [SEQ ID NO: 1], gro.alpha. [SEQ ID NO:2], gro.beta. [SEQ ID NO: 3] or gro.gamma. [SEQ ID NO: 4] or multimers thereof, alone or in conjunction with an anti-infective agent. This invention also relates to a new gro.beta. dimer chemokine.

Method of treating sepsis with chemokines

The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating diseases related to infection by retroviruses.

Retroviral protease inhibitors

The invention relates to the method of preventing and treating sepsis using (S)-5-oxo-L-prolyl-L-.alpha.-glutamyl-L-.alpha.-aspartyl-N.sup.8 -(5-amino-1-carboxypentyl)-8-oxo-N.sup.7 -�N-�N-(5-oxo-L-prolyl)-L-.alpha.-glutamyl!-L-.alpha.-aspartyl!-L-threo-2, 7,8 triaminooctanoyl-lysine �(pGlu-Glu-Asp).sub.2 -Sub-(Lys).sub.2 ! alone or in conjunction with an anti-infective agent.

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West Chester, PA, United States of America

Peter Lawrence DeMarsh