Los Gatos Pharmaceuticals, Inc.

Durect Corporation

Intarcia Therapeutics, Inc.

Peter Langecker

Toshiaki Hino

Kumarapandian Paulvannan

Matthias Steiert

Jan Scicinksi

Andrew R Miksztal

Mark P Davis

Judy Joice

Susan Autio

Vaeling Miller

Dmitri Lissin

Adrian Neil Verity

Steven Halladay

Mark S Moran

Dennis G Blanchett

The present disclosure provides for methods of producing analgesia in a subject. In some cases, methods produce analgesia in a subject undergoing arthroscopic subacromial decompression surgery. The present disclosure also relates to improved sustained release drug delivery systems. In some cases, a composition comprises an active pharmaceutical agent; at least one of sucrose acetate isobutyrate and a polyorthoester; an organic solvent; and 2,6-dimethylaniline, wherein the 2,6-dimethylaniline is present at a level less than 500 ppm. In some cases, a composition comprises bupivacaine N-oxide at a level less than 1 wt %, based on weight of the composition. In some cases, a composition comprises metal present at a level less than 5 ppm. Dosage forms and methods are also provided.

Sustained release drug delivery systems and related methods

Provided herein are camptothecin derivatives and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, cancer using the compounds and pharmaceutical compositions disclosed herein.

Camptothecin derivatives and uses thereof

Provided herein are composite nanoparticles, methods of making composite nanoparticles and methods of using composite nanoparticles to treat or ameliorate various diseases, such as, for example, cancer.

Composite nanoparticles and uses thereof

Growing community of inventors

Monte Sereno, CA, United States of America

Peter Langecker