Eli Lilly and Company

Shionogi Company Limited

Lilly Icos LLC

Icos Corporation

Peter L Oren

Neil R Anderson

Daniel F Lynch

Werner M Seidler

Roger G Harrison

Dale C Harris

John W Clarke

Toshiro Fujii

Robert Lee Benefiel

Toshihiro Ogura

Martha A Kral

Ray F Childers

Robert J Morff

Roger F Harrison

Formulations containing a PDE5 inhibitor, a water-soluble diluent, a lubricant, a hydrophilic binder, a disintegrant, and optional microcrystalline cellulose and/or a wetting agent, and their use in treating sexual dysfunction, are disclosed.

&#x3b2;-carboline pharmaceutical compositions

A superior enteric formulation of the antidepressant drug, fluoxetine, is in the form of enteric pellets of which the enteric layer comprises hydroxypropylmethylcellulose acetate succinate.

Fluoxetine enteric pellets and methods for their preparation and use

An improved method for the treatment of central nervous system disorders comprises treating patients with an enteric fluoxetine formulation.

Method for the treatment of CNS disorders

A superior enteric formulation of the antidepressant drug, duloxetine, is in the form of enteric pellets of which the enteric layer comprises hydroxypropylmethylcellulose acetate succinate.

Duloxetine enteric pellets

Aqueous diffusion coating formulations suitable for use on pharmaceutical dosage forms comprising an admixture of an insoluble polymer component of a copolymer of ethylacrylate and methylmethacrylate and as a hydrophilic component the polysaccharide pullulan. When applied to the substrate of choice, said formulations provide coatings exhibiting good mechanical strength and flexibility.

Film coating formulations

An improved device for containing and administering orally active therapeutic agents is described. A unit dose of a therapeutic agent in free-flowing form is retained and positioned for oral administration in a tube adapted to deliver the dose with a flow of liquid drawn through the tube by normal sipping action of a patient. The combination of small particle size and high flow rates into the alimentary canal allow dosage administration with minimal sensed contact with the oral cavity. The invention is particularly advantageous for the administration of orally active therapeutic agents to pediatric and geriatric patients.

Delivery device for orally administered therapeutic agents

This invention provides a matrix composition for sustained drug delivery which is comprised of an active agent, a hydrophilic polymer and an enteric polymer. The enteric polymer is impermeable to gastric fluids and aids in retarding drug release in regions of low pH, thus allowing lower levels of hydrophilic polymer to be employed. At the pH range of intestinal fluids, this polymer will dissolve and thereby increase the permeability of the dosage form. This approach is useful in sustaining the release of numerous active agents whose solubility declines as the pH is increased, a characteristic of weakly basic drugs. By responding to changes in physiological pH, these sustained release dosage forms have acceptable performance, in spite of variability in the gastrointestinal transit times of the formulation.

Sustained release matrix

The present invention provides sustained release tablets in unit dosage form comprising an active agent which has low aqueous solubility.

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Fishers, IN, United States of America

Peter L Oren