Rohm and Haas Company

Warren-teed Laboratories, Inc.

Peter L DEBenneville

Richard C Johnson

1,4-Dithiinoxides which may be substituted with various radicals, compositions containing said products and methods useful in the treatment of ulcers are disclosed. The products are prepared by oxidation of the correspondingly substituted dithiin.

1,4-Dithiinoxides

Macroreticular polystyrene resin having a surface area of at least 5 and preferably at least 50 square meters/gram and a majority of pores of at least 30 Angstroms diameter is utilized as a solid base support for polypeptide synthesis; linkage of the first amino acid of the peptide to said base being effected through chloromethylation of the base, blocking of the amine function of the acid and esterifying the amino acid with the chloride; the esterification being conducted in the presence of an inert high dielectric constant solvent most preferably acetonitrile. Preferably, the macroreticular solid base support is an aromatic hydrocarbon resin or polymer unsubstituted with nitro or bromo groups, such as the unsubstituted macroreticular polystyrene, above described.

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Philadelphia, PA, United States of America

Peter L DEBenneville