Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Peter Kupser

Christoph Boehm

Juergen Spinke

Norbert Oranth

Thorsten Brueckner

Timo Klein

Uwe Kobold

Jürgen Spinke

Roland Thiele

Tobias Franz

Indranil Mitra

Cornelia Werner

Thorsten BRÜCKNER

Andreas Leinenbach

Christoph BÖHM

Christoph Bohm

Jurgen Spinke

Thorsten Bruckner

Jatin Nandania

Thomas Hoffmann

A clinical diagnostic system is presented and comprises a sample preparation station for automatically preparing samples comprising analytes of interest, a liquid chromatography (LC) separation station comprising a plurality of LC channels and a sample preparation/LC interface for inputting prepared samples into the LC channels. The system further comprises a controller to assign samples to pre-defined sample preparation workflows each comprising a pre-defined sequence of sample preparation steps and requiring a pre-defined time for completion depending on the analytes. The controller further assigns an LC channel for each prepared sample depending on the analytes and plans an LC channel input sequence for inputting the prepared samples that allows analytes from different LC channels to elute in a non-overlapping LC eluate output sequence based on expected elution times. The controller further sets and initiates a start sequence that generates a prepared sample output sequence that matches the LC channel input sequence.

Automated clinical diagnostic system and method using parallel liquid chromatography channels and sample preparation workflows

A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.

Cartridge for dispensing a fluid

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Munich, Germany

Peter Kupser