Sandoz Ag

Nycomed Austria Gmbh

Smithkline Beecham Corporation

Nycomed Imaging As

Other

Sandoz Gmbh

Cenes Limited

Peter Kremminger

Michael Hartmann

Franz Rovenszky

Johann Hiebl

Pradip Kumar Bhatnagar

Johannes Ludescher

Hubert Sturm

Dirk Andries Heerding

Siegfried Wolf

Dagmar Stimmeder

James Francis Callahan

Alan Cuthbertson

Kjell Undheim

Peter Fischer

Mette Husbyn

Hermann Kollmann

Harald Fellier

Heinz Blaschke

Jessie Sandosham

Thomas Christoph

Magne Solbakken

Martin Albert

Andreas Berger

Andreas Koch

Meinolf Lange

Steinar Engelsen

Michael Hutzinger

Erik Agner

Jorg Berg

Peter Nadenik

Ole Storm

The present invention relates to a novel process for preparing ceftaroline fosamil via intermediates of Formulae (1), (3) or (4) of this process. 

Process for preparing ceftaroline fosamil

The present invention relates to a novel process for preparing ceftaroline fosamil as well as to intermediates of Formulae (1), (3) or (4) of this process. 

The present invention relates to a method for the production of organic compounds, in particular sodium (6R,7R)-7-[(Z)-2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-hydroxyimino-acetylamino]-8-oxo-3-[(E)-(R)-1'-(5-methyl-2-oxo-[1,3]-dioxol-4-ylmethoxycarbonyl)-2-oxo-[1,3&#x2032;]bipyrrolidinyl-3-ylidenemethyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate (ceftobiprole medocaril), and compounds of the general formula (1) and of the general formula (2), the compounds themselves and intermediates in the production according to the invention.

Method for the production of ceftobiprole medocaril

This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found that boric or boronic acid derivatives are useful bridging elements for the attachment of a chiral group to a compound containing a carbonyl group to be alkylated. The said borates and boronates are thus useful in a process for the asymmetric alkylation of a carbonyl group in a compound containing a carbonyl group and an anchor group capable of reacting with a boric or boronic acid derivative. The asymmetric alkylation can be carried out by admixing the compound containing a carbonyl group to be alkylated and the anchor group capable of reacting with a boric or boronic acid derivative with a boric or boronic acid derivative, adding a chiral alcohol, and adding an organometallic compound. After the alkylation reaction, the borate and boronate can be easily removed by hydrolysis.

Carbonyl asymmetric alkylation

7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula (I), in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this invention relates to the compound of formula (I) in the form of a salt, optionally in crystalline form, wherein the salt is selected from the group consisting of phosphate, hydrogen phosphate, mesylate, tosylate, sulfate, hydrogen sulfate and sulfamate. 

Cefdinir intermediate

7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula I in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this invention relates to the compound of formula I in the form of a salt, optionally in crystalline form, wherein the salt is selected from the group consisting of phosphate, hydrogen phosphate, mesylate, tosylate, sulfate, hydrogen sulfate and sulfamate.

Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime.

Intermediates in cephalosporin production

Cephalosporin intermediates

The present application relates to compounds of formula (I) wherein A represents oxygen, sulfur or &mdash;NH&mdash;, m is 0-2, and R,, R,, R,, R,and R,have the meanings given in the specification, to a process for their preparation, as well as to their use in the inhibition of cyclooxygenase II.

Substituted derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II

Novel compounds of general formula (I) which have homoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.

Hemoregulatory compounds

The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.

Morphine derivatives with analgesic activity

The present invention relates to novel pyrazine compounds and their use in the regulation of haematopoiesis, in particular in the stimulation of haematopoiesis, and in the treatment of bacterial, viral and fungal diseases.

Pyrazinedicarboxylic-acid derivatives as cell proliferation regulators

Growing community of inventors

Kufstein, Austria

Peter Kremminger