Schering Corporation

Peter Korakas

Deen Tulshian

Duane A Burnett

Wen-Lian Wu

Thavalakulamgara K Sasikumar

Lisa S Silverman

Julius J Matasi

Martin Domalski

Li Qiang

Brian Alexander McKittrick

Elizabeth M Smith

Joel M Harris

Chad E Bennett

Chad E Knutson

Hyunjin M Kim

Eugenia Y Kiselgof

Martin S Domalski

Sasikumar K Thavalakulamgara

In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J-J, X, and R-Rare as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease. 

mGluR1 antagonists as therapeutic agents

Disclosed are compounds of the formula: and compounds of the formula: wherein R, R, R, R, R, u and v are as defined herein. Also disclosed are methods of treating pain (e.g., inflammatory pain, chronic pain, and neuropathic pain), methods of treating diabetes, and methods of inhibiting the absorption of cholesterol using compounds of formula I or IIA.

Azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabolism

In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J-J, X, and R&#x2014;Rare as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease. 

Growing community of inventors

Bound Brook, NJ, United States of America

Peter Korakas