Roche Diagnostics Operations, Inc.

Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Albert-ludwigs-universitaet Freiburg

Albert-ludwigs-universitat Freiburg

Cytena Bioprocess Solutions Co., Ltd.

Hahn-schickard-gesellschaft Fuer Angewandte Forschung E.v.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Biofluidix Gmbh

Actome Gmbh

Peter Koltay

Juergen Spinke

Christoph Boehm

Stefan Zimmermann

Laurent Tanguy

Christian Arnold Litterst

Steffen Eccarius

Nadine Losleben

Chris Steinert

Andre Gross

Jonas Schöndube

Stefan Borja Bammesberger

Cheng-Han Tsai

Andreas Ernst

Thorsten Brueckner

Norbert Oranth

Timo Klein

Jürgen Spinke

Tobias Metz

Klaus Mutschler

Azmi Yusof

Sabrina Kartmann

Csaba Jeney

Jonas Schondube

Tsai Chenghan

Thorsten BRÜCKNER

Christoph BÖHM

The invention relates to a device for processing a liquid sample, comprising a carrier that has at least one well for receiving the liquid sample, a processing unit for carrying out at least one processing step, and an actuating apparatus, which has an electrical control or regulating unit for controlling or regulating the processing step carried out by means of the processing unit, wherein the actuating apparatus, in particular the control or regulating unit, is mounted on the processing unit. The device is characterized in that the processing unit is mounted on the carrier.

Device for processing a liquid sample

The invention relates to a method for processing a liquid sample situated in a receptacle, wherein an attachment device is attached to the receptacle such that at least one fluid line protrudes into the liquid sample and a fluid is directly dispensed into the liquid sample through the fluid line and/or a portion of the liquid sample is aspirated into the fluid line.

Method for processing a liquid sample

A dispensing assembly comprising a cartridge holder is presented. The cartridge holder can receive a cartridge for dispensing a fluid. The cartridge can comprise a reservoir for receiving the fluid. The reservoir can comprise an outlet. The reservoir can have an adjustable volume for forcing the fluid through the outlet. The cartridge can further comprise a nozzle for dispensing the fluid. The nozzle can be connected to the outlet. The dispensing assembly can further comprise an actuator for actuating the adjustable volume. The dispensing assembly can further comprise an impulse generator for imparting an impulse to the nozzle. The impulse generator can comprise an actor for contacting the nozzle. The dispenser assembly can further comprise a controller for controlling the actor and the impulse generator.

Dispensing assembly

A valve for dispensing a fluid comprising a dry portion and a wet portion is presented. Only the wet portion is contacted by the fluid. The wet portion comprises a fluid dispenser unit having a inlet opening, a capillary nozzle providing a fluid outlet, a cavity, the capillary nozzle having an end within the cavity, and a plunger. The plunger moves within the cavity into an opening position allowing an inflow of the fluid through the inlet opening through the cavity and an outflow of the fluid through the capillary nozzle. The plunger has a sealing surface directed towards the end of the capillary nozzle. The plunger moves into a closing position for sealing the end of the capillary nozzle with the sealing surface. The dry portion comprises a closing component for exercising a magnetic closing force onto the plunger for attracting the plunger into the closing position.

Valve for dispensing a fluid

A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.

Cartridge for dispensing a fluid comprising a reagent

A dispenser for dispensing a fluid is presented. The dispenser comprises a compressible elastomeric fluid conduit having a first end and a second end for flowing the fluid from the first end to the second end, a first check valve and a second check valve distanced in the conduit for forming a fluid chamber, and an actor for compressing the fluid chamber for dispensing a portion of the fluid. At least the second check valve is a duckbill valve. The second check valve is located at the second end of the conduit. The second check valve has sealing lips that extend beyond the second end of the conduit.

Microfluidic dispenser, cartridge and analysis system for analyzing a biological sample

A device for dispensing or receiving a liquid volume includes a liquid reservoir having an outlet, a pressure generator which provides a compressible enclosed gas volume of a constant amount of substance with a pressure, wherein the gas volume is in direct or indirect fluidic contact with the liquid in the liquid reservoir, a dosing device coupled to the outlet of the liquid reservoir and operable in order to enable the liquid to pass the outlet, a pressure sensor arranged to measure a current pressure in the gas volume and to output an output signal indicating the current pressure in the gas volume and a controller coupled to the pressure generator, the dosing device and the pressure sensor.

Device and method for dispensing or receiving a liquid volume

A device for generating a drop of a primary liquid is described, including: a reservoir fillable with the primary liquid, a pressure generation device for generating a hydraulic pressure on the primary liquid, at least one inlet channel for introducing a secondary fluid, and a channel having a flow cross-section transverse to a main flow direction, wherein the flow cross-section includes a main region and at least one sub-region extending from the main region, designed such that the primary liquid can be held in the main region by capillary forces, and the secondary fluid can be held in the sub-region by capillary forces, wherein the reservoir is fluidically connected to a first end of the channel via an output opening, and the at least one inlet channel is also fluidically connected to the channel, and wherein the pressure generation device is implemented to apply a hydraulic pressure to the primary liquid, whereby the same is moved along the channel and output at a second end of the channel as free-flying drop.

Device and method for generating a drop of a liquid

An apparatus for dispensing one or more cells or particles confined in a free flying droplet has a droplet generating device configured to eject out of an orifice a free flying droplet of a suspension of cells or particles. The droplet generating device has a branch-less one-way channel having the orifice at one end thereof. A device for detecting information on cells or particles located in an observation volume of the suspension within the branch-less one-way channel is provided. An ejected droplet is directed to a first position or a second position depending on the detected information.

Apparatus and method for dispensing cells or particles confined in a free flying droplet

The invention relates to a method for operating a direct oxidation fuel cell in which the fuel cell is supplied generally with methanol via a transport device for the fuel. The invention likewise relates to a corresponding arrangement comprising a direct oxidation fuel cell, a fuel reservoir and at least one device for transporting the fuel through the fuel cell.

Method for operating a direct oxidation fuel cell and corresponding arrangement

The invention relates to a method for operating a direct oxidation fuel cell in which at least one fluid fuel is transported from a fuel reservoir via a fluid distribution structure to a membrane electrode assembly, the transport of the fuel being effected passively, i.e. without convection. Furthermore, the invention relates to a corresponding direct oxidation fuel cell.

Direct oxidation fuel cell and method for operation thereof

The invention relates to a device which comprises a channel () carrying a flowable medium. The due operation and/or maintenance of the device is associated with the formation of inclusions () inside the channel () of a fluid or gas distinct from the aforementioned medium. The channel () is configured in such a manner that the inclusions are moved towards a channel exit () by capillary forces. The invention also relates to a method for removing inclusions () from corresponding devices.

Device with a channel conducting a flowable medium and a method for removing inclusions

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Freiburg, Germany

Peter Koltay