Boehringer Mannheim Gmbh

Peter Kirch

Christian Klein

Manfred Baier

Werner Stock

Klaus P Kaspar

The present invention provides compounds of the general formula: ##STR1## wherein A is an amine-substituted aromatic radical and X is a hydrocarbon radical containing up to 10 carbon atoms. The present invention also provides a process for the preparation of these compounds. Furthermore, the present invention is concerned with the use of the compounds for introducing SH groups into tyrosine.

Certain -N-(amino benzoyl)-N'-(pyridyldithioalkanoyl)-hydrazines and

The present invention provides a process for the quantitative determination of a polyvalent antigen by incubation with three different receptors of which the first (R1) and the third (R3) are present in liquid phase and are bindable with the antigen, the second receptor (R2) is present in solid phase and is bindable with receptor (R1), and receptor (R3) carries a label and does not cross-react with (R1) and (R2), separation of the solid phase from the liquid phase and measurement of the label in one of the phases, wherein a first receptor (R1) is used which consists of at least two antibody molecules or antibody molecule fragments bound with one another, at least one of which binds specifically with the antigen to be determined. The present invention also provides a reagent for the quantitative determination of a polyvalent antigen containing three receptors (R1, R2 and R3) of which (R1) and (R3) are soluble and bindable with the antigen, (R3) is labelled and does not cross-react with (R1) and (R2), wherein (R1) consists of at least two antibody molecules or antibody molecule fragments bound with one another, at least one of which binds specifically with the antigen to be determined.

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Rott, Germany

Peter Kirch