Roche Diagnostics Operations, Inc.

F. Hoffmann-la Roche Ag

Peter Kern

Herbert Von Der Eltz

Gerald F Sigler

Erasmus Huber

Raymond Hui

Ina Deras

Mitali Ghoshal

Sonja Offner

Josef Endl

Richard Terry Root

Josef Platzer

Sigrun Metz

Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.

Protease inhibitor conjugates and antibodies useful in immunoassay

Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.

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Penzberg, Germany

Peter Kern