Hoffmann-la Roche Inc.

Peter Karl Matzinger

Michelangelo Scalone

Ulrich Zutter

Tatsuo Hoshino

Dieter Seebach

Teruhide Sugisawa

Hans G Leuenberger

Setsuko Ojima

Erich Hochuli

Max F Zuger

Fiona Gruninger

A novel process for the manufacture of compounds of the formulawherein Rand Rindependently represent aroyl. The present invention also concerns novel intermediates used in the novel process for making compounds of formula I.

Asymmetric synthesis process

A novel process for the manufacture of compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently represent aroyl. The present invention also concerns novel intermediates used in the novel process for making compounds of formula I.

Asymmetric synthesis of azepines

Assymetric synthesis of azepines

A tocopherol cyclase is produced in homogenous form which acts on phytyl benzoquinol derivatives to produce R', R', R'-tocopherols enantioselectively. The cyclase has a molecular weight of from about 48 kD to about 50 kD as determined by SDS-PAGE. The cyclase is isolated from Chlorella protothecoides, Dunaliella salina and wheat leaves of the Fidel variety.

Tocopherol cyclase isolated from Chlorella protothecoides, Dunaliella

The present invention concerns a novel process for the microbiological manufacture of L-ascorbic acid from L-gulono-gamma-lactone, a process for preparing the enzyme being responsible for the microbiological oxidation of L-gulono-gamma-lactone, and said enzyme as a homogeneous protein, which is a L-gulono-gamma-lactone dehydrogenase.

L-gulono-gamma-lactone-dehydrogenase for producing vitamin C

The manufacture of optically active compounds of the formula ##STR1## wherein R.sup.1 signifies alkyl, phenyl or benzyl and R.sup.2 signifies hydrogen or a customary ester residue, by the fermentative reduction of compounds of the formula ##STR2## wherein R.sup.1 and R.sup.2 have the above significance. The compounds obtained are valuable intermediates in organic syntheses.

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Rodersdorf, Switzerland

Peter Karl Matzinger