American Cyanamid Company

Focal, Inc.

Tyco Group S.a.r.l.

Peter K Jarrett

Donald J Casey

Louis Rosati

Ronald S Rudowsky

Amarpreet S Sawhney

Arthur J Coury

Michelle D Lyman

Amapreet S Sawhney

Jeffrey Alan Hubbell

Chandrashekhar Prabhakar Pathak

Stephen Jack Herman

Patrick K Campbell

Laurence A Roth

George Jessup

John W Maney

Chris Martin

Kevin M Berrigan

Leonard T Lehmann

Luis Z Avila

Shikha P Barman

David J Enscore

Steven L Peake

Stephen D Goodrich

Douglas J Weaver

Fei Yao

William C Nason

Michelle D Powell

David W Wang

James W Dwyer

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.

Compliant tissue sealants

A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.

Apparatus and methods for intraluminal photothermoforming

Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

Polymerizable biodegradable polymers including carbonate or dioxanone linkages

A deformable surgical repair device is manufactured from a block or graft copolymer. The copolymer comprises a plurality of first linkages selected from the group consisting of glycolic acid ester and lactic acid ester linkages, and mixtures thereof, and a plurality of second linkages selected from the group consisting of 1,3-dioxan-2-one; 1,4-dioxan-2-one and .epsilon.-caprolactone linkages. The plurality of first linkages comprises at least about 50 up to about 90 mole percent of the copolymer. In an alternative Claim, the deformable surgical repair device is manufactured from a blend of a first and a second absorbable polymer. The first absorbable polymer comprises a plurality of linkages selected from the group consisting of glycolic acid ester and lactic acid ester linkages, and mixtures thereof. The second absorbable polymer comprises a plurality of linkages selected from the group consisting of 1,3-dioxan-2-one; 1,4-dioxan-2-one and .epsilon.-caprolactone linkages. The first absorbable polymer comprises at least about 50 up to about 90 weight percent of the blend. The device is useful in fracture fixation.

Deformable absorbable surgical device

Polymerizable biodegradable polymers including carbonate or dioxanone

Methods for intraluminal photothermoforming

Polymeric article for intraluminal photothermoforming

Apparatus for intraluminal photothermoforming

This invention relates to materials for medical or veterinary use that possess considerably improved properties with regard to friction. The invention also relates to the production of such materials from existing materials that possess suitable bulk properties, but inappropriate frictional properties. This invention also relates to a hydrophilic coating material that provides improved frictional properties.

Coating for tissue drag reduction

Growing community of inventors

Southbury, CT, United States of America

Peter K Jarrett